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Pioneering Induction Of Bone Formation Using Embryonic Stem Cells

Date:
May 17, 2008
Source:
University of Twente
Summary:
Researchers have successfully creating bone tissue "in vivo", using embryonic stem cells. They imitated bone formation in embryos and children, which uses cartilage as a template. This new approach appears to be a promising way of repairing bone defects. Previous attempts to create bone using embryonic stem cells were unsuccessful. In the lab, there was clear evidence that these stem cells were differentiating into the bone lineage "in vitro", however this process stalled after implantation and no bone tissue was formed. Yet, this approach did lead to bone formation when cultured adult stem cells from bone marrow were used. This direct approach is, amongst others, involved in the formation of the bone found in the skull.

Cross section showing “endochondral ossification”: bone formation on a cartilage template.
Credit: Image courtesy of University of Twente

Researchers at the University of Twente break new ground by successfully creating bone tissue “in vivo”, using embryonic stem cells. They imitated bone formation in embryos and children, which uses cartilage as a template. This new approach appears to be a promising way of repairing bone defects.

Previous attempts to create bone using embryonic stem cells were unsuccessful. In the lab, there was clear evidence that these stem cells were differentiating into the bone lineage “in vitro”, however this process stalled after implantation and no bone tissue was formed. Yet, this approach did lead to bone formation when cultured adult stem cells from bone marrow were used. This direct approach is, amongst others, involved in the formation of the bone found in the skull. The researchers at Twente have now adopted a different approach.

Unexpected

While searching for a suitable scaffold to use for cartilage tissue engineering with mouse embryonic stem cells, the researchers selected a ceramic material that is often used as bone void filler. Other materials appeared to be unsuitable or they made it difficult to locate the implanted cells. In the lab, mouse embryonic stem cells were seeded onto this ceramic material and induced into the developmental pathway leading to cartilage formation.

Following implantation under the skin of a mouse, however, the cartilage tissue developed further, and was replaced by bone. Bone formation via cartilage as a template proved to be an efficient, if unexpected, approach. Furthermore, this is the way in which most of the bones in the embryo are formed. Bone growth in children also occurs via this process, known as endochondral ossification.

Repair

In their article, the researchers show that bone tissue is also formed in a bone defect. To demonstrate this, a scaffold with cells that had already formed cartilage, was implanted into a rat with a defect in its skull. Besides under the skin, bone was also formed in this bone defect. Therefore, this approach seems to be a promising new technique for repairing damaged bone.


Story Source:

The above story is based on materials provided by University of Twente. Note: Materials may be edited for content and length.


Journal Reference:

  1. Endochondral bone tissue engineering using embryonic stem cells. Jojanneke Jukes, Sanne Both, Anouk Leusink, Lotus Sterk, Clemens van Blitterswijk and Jan de Boer. Proceedings of the National Academy of Sciences of the United States of America (PNAS). May 13, 2008. [link]

Cite This Page:

University of Twente. "Pioneering Induction Of Bone Formation Using Embryonic Stem Cells." ScienceDaily. ScienceDaily, 17 May 2008. <www.sciencedaily.com/releases/2008/05/080514091744.htm>.
University of Twente. (2008, May 17). Pioneering Induction Of Bone Formation Using Embryonic Stem Cells. ScienceDaily. Retrieved April 15, 2014 from www.sciencedaily.com/releases/2008/05/080514091744.htm
University of Twente. "Pioneering Induction Of Bone Formation Using Embryonic Stem Cells." ScienceDaily. www.sciencedaily.com/releases/2008/05/080514091744.htm (accessed April 15, 2014).

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