Featured Research

from universities, journals, and other organizations

Fat Chance: Brown Vs. White Fat Cell Specification

Date:
May 14, 2008
Source:
Cold Spring Harbor Laboratory
Summary:
Scientists elucidate the molecular pathway that induces cells to become energy-burning brown fat cells as opposed to energy-storing white fat cells.

In the May 15th issue of Genes & Development, Dr. Bruce Spiegelman (Dana Farber Cancer Institute) and colleagues elucidate the molecular pathway that induces cells to become energy-burning brown fat cells as opposed to energy-storing white fat cells.

Since brown adipose tissue (BAT) and white adipose tissue (WAT) have essentially antagonistic roles in energy homeostasis (WAT stores calories; BAT burns them), insight into the genetics of adipocyte specification is particularly interesting to those contemplating the conversion of white-to-brown fat cells as a therapeutic treatment for obesity and obesity-related disorders.

Dr. Spiegelman and colleagues previously identified the protein PRDM16 as a dominant regulator of brown fat cell determination. PRDM is selectively expressed in BAT, where it activates brown fat-specific gene expression and represses white fat-specific gene expression. The scientists have now answered the complicated question: How?

Dr. Spiegelman and colleagues discovered that PRDM16 is able to switch between an association with the co-repressor proteins, CtBP-1 and -2, to inhibit WAT genes, and the co-activator protein PGC-1alpha, to induce BAT gene expression. Thus, PRDM16 can differentially regulate fat cell gene expression programs to favor the formation of BAT.

Dr. Spiegelman feels that "As we learn more about the molecular mechanisms by which PRDM16 acts, we hope to be able to use this pathway to modulate metabolism in living organisms to counteract obesity and diabetes".


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Fat Chance: Brown Vs. White Fat Cell Specification." ScienceDaily. ScienceDaily, 14 May 2008. <www.sciencedaily.com/releases/2008/05/080514171819.htm>.
Cold Spring Harbor Laboratory. (2008, May 14). Fat Chance: Brown Vs. White Fat Cell Specification. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2008/05/080514171819.htm
Cold Spring Harbor Laboratory. "Fat Chance: Brown Vs. White Fat Cell Specification." ScienceDaily. www.sciencedaily.com/releases/2008/05/080514171819.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins