Featured Research

from universities, journals, and other organizations

Survivors Of Childhood Cancers Treated With Cyclophosphamide More Likely To Develop Bladder Cancer, Study Shows

Date:
May 15, 2008
Source:
American Urological Association
Summary:
Survivors of childhood cancers treated with the chemotherapy drug cyclophosphamide were five times more likely to develop bladder cancer later in life than the general population.

Survivors of childhood cancers treated with the chemotherapy drug cyclophosphamide were five times more likely to develop bladder cancer later in life than the general population. Results of this new research from the United Kingdom were presented during the Annual Scientific Meeting of the American Urological Association (AUA). Survivors originally diagnosed at zero to four years of age and those diagnosed with retinoblastoma, leukemia and non-Hodgkin’s lymphoma were at a particularly higher risk.

Researchers analyzed British Childhood Cancer Survivor Study (BCCSS) records of patients diagnosed under the age of 15 with leukemia, non-Hodgkin’s lymphoma, retinoblastoma or soft tissue sarcoma and subsequently treated with cyclophosphamide or radiotherapy. Patients in the study cohort had a survival rate of at least five years. These data were compared to records from the National Health Service Central Register through 2004 to identify patients who subsequently developed bladder cancer to determine whether treatment choice could be associated with future bladder cancer development.

Bladder cancer was found in 19 patients (5.3 times what was expected), with a mean follow up (post-five-year survival) of 18.9 years. Further analysis of follow-up intervals (20, 30, 40 and 50 years post-five-year survival) indicated that the risk of developing bladder cancer increases with time. The cumulative percentage of survivors diagnosed at 20, 30, 40 and 50 years was 0.02 percent, 0.08 percent, 0.37 percent and 0.71 percent, respectively.

Cyclophosphamide, an immunosuppressive drug used to treat several types of cancer, is known to cause bladder damage that predisposes patients to subsequent bladder cancer.


Story Source:

The above story is based on materials provided by American Urological Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gurung PM, Leiper A, Woodhouse CRJ, Hawkins MM: Risk of bladder cancer after childhood cancer. J Urol, suppl., 2008; 179: 322, abstract 934. [link]

Cite This Page:

American Urological Association. "Survivors Of Childhood Cancers Treated With Cyclophosphamide More Likely To Develop Bladder Cancer, Study Shows." ScienceDaily. ScienceDaily, 15 May 2008. <www.sciencedaily.com/releases/2008/05/080515072815.htm>.
American Urological Association. (2008, May 15). Survivors Of Childhood Cancers Treated With Cyclophosphamide More Likely To Develop Bladder Cancer, Study Shows. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2008/05/080515072815.htm
American Urological Association. "Survivors Of Childhood Cancers Treated With Cyclophosphamide More Likely To Develop Bladder Cancer, Study Shows." ScienceDaily. www.sciencedaily.com/releases/2008/05/080515072815.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins