Featured Research

from universities, journals, and other organizations

New Pharmacological Effect Of Jianpi Huoxue Decoction

Date:
May 20, 2008
Source:
World Journal of Gastroenterology
Summary:
Chinese herbs, Jianpi Huoxue decoction, which have been shown to suppress alcoholic liver and intestinal injury, can inhibit cytokine expression induced by lipopolysaccharide in the liver. This pharmacological effect is associated with its inhibition on the LPS-activated Kupffer cell signal pathway.

Professor Yi-Yang Hu and his colleagues confirmed that Jianpi Huoxue decoction (JHD) reduced the cytokine expression induced by lipopolysaccharide (LPS) and inhibited some targets in LPS-activated Kupffer cell signal pathway. This may provide new insight on the mechanism of JHD on alcoholic liver injury.

This study was performed by a team led by Professor Hu, from the Institute of Liver Diseases, Shuguang Hospital, affiliated with the Shanghai University of Traditional Chinese Medicine.

This study confirmed one of the possible mechanisms of JHD on alcoholic liver injury, that it inhibits some targets in LPS-activated Kupffer cell signal pathway, such as the specific molecular marker of macrophage, CD68, phosphorylated inhibit- kappaB (p-I kappaB) protein expression, the endotoxin receptor and toll-like receptor (TLR2) mRNA expression.

JHD has proven to be effective in suppressing alcoholic liver and intestinal injury induced by the Lieber-Decarli liquid diet in rats. It has also proven to be effective in suppressing the concentration of LPS in plasma. Study has demonstrated the inhibitory effect of JHD on LPS-induced cytokine secretion pathway, but the relationship between endotoxin receptors and LPS should be investigated in more detail. Such research would contribute to further observing the effect of JHD on endotoxin receptors.

The "two-hits" theory brought great advances in pathogenesis research of alcoholic liver injury (ALD). At present, most attention is focused on the mechanism of the endotoxin or LPS signal pathway involved in ALD. The function of Kupffer cells and their cytokine secretion pathway when exposed to LPS has become the hotspot of this field. This research might provide a new effective method for alcoholic liver injury prevention and treatment.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Peng JH, Hu YY, Cheng Y, Han C, Xu LL, Feng Q, Chen SD, Tao Q, Li HS, Li XM. Effect of JIANPI HUOXUE decoction on inflammatory cytokine secretion pathway in rat liver with lipopolysaccharide challenge. World J Gastroenterol 2008;14(12):1851-1857 [link]

Cite This Page:

World Journal of Gastroenterology. "New Pharmacological Effect Of Jianpi Huoxue Decoction." ScienceDaily. ScienceDaily, 20 May 2008. <www.sciencedaily.com/releases/2008/05/080520122804.htm>.
World Journal of Gastroenterology. (2008, May 20). New Pharmacological Effect Of Jianpi Huoxue Decoction. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2008/05/080520122804.htm
World Journal of Gastroenterology. "New Pharmacological Effect Of Jianpi Huoxue Decoction." ScienceDaily. www.sciencedaily.com/releases/2008/05/080520122804.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins