Featured Research

from universities, journals, and other organizations

Clinical Investigation Meets Computer Simulation To Analyze Risk Factor Of Heart Disease

Date:
May 27, 2008
Source:
Public Library of Science
Summary:
Researchers have developed a novel, computer-based strategy to study plasma lipoprotein profiles considered a major predictor of cardiovascular disease. Lipoproteins are the "container ships" in our blood that transport lipids (fats) such as cholesterol and triglycerides to various tissues; they differ largely in size and "cargo" composition. Abnormalities in the amount of certain lipoprotein fractions are considered a major risk factor for atherosclerosis and CVD.

German researchers at the Charité -- Universitätsmedizin Berlin and the Max-Delbrück-Center Berlin have developed a novel, computer-based strategy to study plasma lipoprotein profiles considered a major predictor of cardiovascular disease (CVD).

Lipoproteins are the "container ships" in our blood that transport lipids (fats) such as cholesterol and triglycerides to various tissues; they differ largely in size and "cargo" composition. Abnormalities in the amount of certain lipoprotein fractions are considered a major risk factor for atherosclerosis and CVD. To identify patients at risk for CVD, selected lipoprotein fractions - "bad" Low Density Lipoproteins (LDL) and "good" High Density Lipoproteins (HDL) - are routinely monitored in clinical practice (lipoprotein profile).

The decrease of LDL cholesterol is a principal target in cardiovascular preventive strategies. Growing evidence claims that evaluating the lipoprotein profile in greater detail (e.g. looking at subfractions of LDL and HDL) may provide more reliable prognostic information than routine measurement of LDL cholesterol levels, but this needs elaborate and expensive work.

Katrin Hübner and colleagues, therefore, conceived of designing a mathematical model to provide computer calculations of lipoprotein profiles which take into account the entire "fleet" of lipoproteins in blood plasma by simulating every single lipoprotein ("ship"). This way, studying lipoprotein profiles in any desired detail is possible. The model may also be broadly applied to infer relationships between a patient's lipoprotein profile and the underlying biochemical processes.

The calculations were verified by comparing them with clinically measured lipoprotein profiles of healthy subjects and pathological cases of known lipid disorders. The researchers show that more detailed lipoprotein profiles can reveal possibly clinically-relevant abnormalities in the lipid values which would remain undetected by evaluating only LDL and HDL.

Together with independent information on diet and genetic variations this increases the potential for patient-oriented diagnosing of molecular causes for observed abnormal lipoprotein profiles.

 This work was in part associated to the German Systems Biology Initiative HepatoSys. Clinical data of lipoprotein profiles were generated in collaboration with the University Medical Center Freiburg.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hübner K, Schwager T, Winkler K, Reich J-G, Holzhu¨ tter H-G (2008) Computational Lipidology: Predicting Lipoprotein Density Profiles in Human Blood Plasma. PLoS Comput Biol 4(5): e1000079. doi:10.1371/journal.pcbi.1000079 [link]

Cite This Page:

Public Library of Science. "Clinical Investigation Meets Computer Simulation To Analyze Risk Factor Of Heart Disease." ScienceDaily. ScienceDaily, 27 May 2008. <www.sciencedaily.com/releases/2008/05/080522210021.htm>.
Public Library of Science. (2008, May 27). Clinical Investigation Meets Computer Simulation To Analyze Risk Factor Of Heart Disease. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2008/05/080522210021.htm
Public Library of Science. "Clinical Investigation Meets Computer Simulation To Analyze Risk Factor Of Heart Disease." ScienceDaily. www.sciencedaily.com/releases/2008/05/080522210021.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) — An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) — Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) — Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) — It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins