Featured Research

from universities, journals, and other organizations

Coronary Calcium Distribution Tied To Heart Attack Risk

Date:
May 28, 2008
Source:
Radiological Society of North America
Summary:
A new calcium scoring method may better predict a person's risk of heart attack, according to a new multicenter study. Calcium coverage scoring takes into account not only the amount of calcified plaque build-up in the coronary arteries, but also its distribution.

A new calcium scoring method may better predict a person's risk of heart attack, according to a new multicenter study. Calcium coverage scoring takes into account not only the amount of calcified plaque build-up in the coronary arteries, but also its distribution.

"Now we know that the location of the calcium in the arteries is particularly important in estimating a patient's potential risk," said the study's lead author Elizabeth Brown, Sc.D., research assistant professor in the Department of Biostatistics at the University of Washington in Seattle.

Heart disease is the leading cause of death in the U.S. Each year, 700,000 Americans die of heart disease, according to the Centers for Disease Control and Prevention. The most common form of heart disease in the U.S. is coronary artery disease, which is caused by a build-up of calcific plaque in the coronary arteries leading to the heart. The current standard of coronary calcium measurement gauges only the amount of calcium present in the arteries, not its spatial distribution.

"Currently, physicians only see the result in terms of an overall score designed to measure the amount of calcified plaque," Dr. Brown said. "This new approach will provide physicians with a measure of the proportion of the arteries affected."

The Multi-Ethnic Study of Atherosclerosis (MESA) began in July 2000. The prospective study included 6,814 men and women between the ages of 45 and 84. The researchers compared CT image data for 3,252 participants with calcific plaque to data collected from 3,416 patients without calcific plaque. (Due to lack of sufficient CT image data, 146 additional MESA participants were excluded from this analysis.) A calcium coverage score was developed to estimate the percentage of coronary arteries affected by plaque.

The patients were then followed up for a median period of 41 months to determine if there was a relationship between the distribution of calcium shown in the CT images and the likelihood heart attack or other cardiac event.

The results showed that diabetes, hypertension and dyslipidemia (abnormal concentrations of lipids [fats] or lipoproteins in the blood) were highly associated with calcium coverage score. The study also found that the calcium coverage score--which takes into account the location of the calcium--was a better predictor of future cardiac events than currently used measures that gauge only the amount of calcium present. On average, compared to patients without diabetes, patients with diabetes had 44 percent more of their coronary arteries affected by plaque. A twofold increase in calcium coverage score indicated a 34 percent increase in risk of heart attack or other serious cardiac event and a 52 percent increase in the risk of any cardiac event.

"Calcium coverage scoring has the potential to improve our estimate of a patient's risk for adverse clinical outcomes, such as heart attacks or death," Dr. Brown said.


Story Source:

The above story is based on materials provided by Radiological Society of North America. Note: Materials may be edited for content and length.


Journal Reference:

  1. Elizabeth R. Brown, Richard A. Kronmal, David A. Bluemke, Alan D. Guerci, J. Jeffrey Carr, Jonathan Goldin, and Robert Detrano. Coronary Calcium Coverage Score: Determination, Correlates, and Predictive Accuracy in the Multi-Ethnic Study of Atherosclerosis. Radiology, 2008; 247: 669-675 DOI: 10.1148/radiol.2473071469

Cite This Page:

Radiological Society of North America. "Coronary Calcium Distribution Tied To Heart Attack Risk." ScienceDaily. ScienceDaily, 28 May 2008. <www.sciencedaily.com/releases/2008/05/080527084259.htm>.
Radiological Society of North America. (2008, May 28). Coronary Calcium Distribution Tied To Heart Attack Risk. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2008/05/080527084259.htm
Radiological Society of North America. "Coronary Calcium Distribution Tied To Heart Attack Risk." ScienceDaily. www.sciencedaily.com/releases/2008/05/080527084259.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins