Featured Research

from universities, journals, and other organizations

Sex, Age And Ethnicity Assciated With Colorectal Cancer Survival

Date:
May 31, 2008
Source:
University of Southern California
Summary:
The interaction of sex, age and ethnicity has a significant impact on overall survival in metastatic colorectal cancer patients, a new study suggests. Researchers found that pre-menopausal women with metastatic colorectal cancer (18-44 years old) lived longer than younger men, while older women (75 and older) had significantly worse overall survival than older men.

The interaction of sex, age and ethnicity has a significant impact on overall survival in metastatic colorectal cancer (MCRC) patients, a study led by researchers at the University of Southern California (USC) and USC/Norris Comprehensive Cancer Center suggests.

While age and ethnicity are well-established factors that impact survival in colorectal cancer, the study found that gender also plays an important role in overall survival, says Andrew Hendifar, M.D., MPH, fellow in the division of hematology/oncology at the Keck School of Medicine of USC and lead author of the study. Researchers found that pre-menopausal women with metastatic colorectal cancer (18-44 years old) lived longer than younger men, while older women (75 and older) had significantly worse overall survival than older men.

The study adds to the growing evidence that female hormones are protective for colon cancer, researchers say.

"This study provides further evidence that estrogen may play an important role not only in colon cancer development but also progression of the disease, and may impact how we develop therapies for women and men with colon cancer," says Heinz-Josef Lenz, M.D., professor of medicine at the Keck School of Medicine and a senior investigator on the study.

Researchers screened 56,598 patients with metastatic colorectal cancer from 1988 to 2003, using the Surveillance, Epidemiology and End Results (SEER) registry. Models were created using the patients' age at diagnosis, sex, ethnicity and overall survival. Independent of age, there were no survival differences between men and women with MCRC. However, when age was added to the model, sex became significantly associated with survival across all ethnicities.

Researchers also found that certain ethnicities had better overall survival than others. Namely, Hispanics and Asians have better outcomes than Caucasians and African-Americans. Further studies in this area should look at how certain diets or specific surroundings contribute to the development of colorectal cancer, Hendifar notes.

"The data warrant further studies to determine the role of estrogen and ethnicity in colorectal cancer development," he says. "In the future, we may tailor different treatments for men and women."

The study was funded by grants in honor of Sharon A. Carpenter and from the Dhont Family Foundation.

The results of the study will be presented at a poster discussion "Gastrointestinal (Colorectal) Cancer" on Sunday, June 1, at the 2008 annual meeting of the American Society of Clinical Oncology (ASCO) held at McCormick Place in Chicago. The authors and title are: A.E. Hendifar, G. Lurje, F. Lenz, A. Pohl, P. Manegold, K. Togawa, H. Husain, H. Lenz, D. Yang, "Sex, age and ethnicity are associated with survival in metatstatic colorectal cancer."


Story Source:

The above story is based on materials provided by University of Southern California. Note: Materials may be edited for content and length.


Cite This Page:

University of Southern California. "Sex, Age And Ethnicity Assciated With Colorectal Cancer Survival." ScienceDaily. ScienceDaily, 31 May 2008. <www.sciencedaily.com/releases/2008/05/080529091123.htm>.
University of Southern California. (2008, May 31). Sex, Age And Ethnicity Assciated With Colorectal Cancer Survival. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2008/05/080529091123.htm
University of Southern California. "Sex, Age And Ethnicity Assciated With Colorectal Cancer Survival." ScienceDaily. www.sciencedaily.com/releases/2008/05/080529091123.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins