Featured Research

from universities, journals, and other organizations

Tamoxifen Might Be Effective In The Treatment Of Leishmania Amazonensis Infections

Date:
June 10, 2008
Source:
Public Library of Science
Summary:
Researchers have shown the efficacy of an alternative drug against Leishmania amazonensis, one of the species that causes cutaneous leishmaniasis in South America. Tamoxifen -- a medication widely used in the treatment and prevention of breast cancer -- fights the parasitic disease in experimentally infected mice.

Researchers from the University of São Paulo, Brazil, have shown the efficacy of an alternative drug against Leishmania amazonensis, one of the species that causes cutaneous leishmaniasis in South America. Tamoxifen -- a medication widely used in the treatment and prevention of breast cancer -- fights the parasitic disease in experimentally infected mice.

Unicellular parasites of Leishmania genus are the causative agents of leishmaniasis. Treatment of leishmaniasis requires the administration of toxic and poorly tolerated drugs. Having previously demonstrated that tamoxifen was active against parasites in vitro, the authors now show its efficacy in a rodent model of infection with L. amazonensis.

The Brazilian group, led by Silvia Uliana, observed that infected mice treated with 20 mg/kg/day of tamoxifen for 2 weeks showed a significant reduction in parasite burden. Researchers also detected a notable delay in the development of skin ulcers, a typical symptom of the disease caused by L. amazonensis.

The promising results presented in this study, coupled with the fact that tamoxifen's safety and pharmacological profiles in humans are well established, point to a new alternative in the treatment of leishmaniasis. Further trials will be necessary in other experimental models of infection before the drug is tested in humans.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Miguel et al. Tamoxifen Is Effective in the Treatment of Leishmania amazonensis Infections in Mice. PLoS Neglected Tropical Diseases, 2008; 2 (6): e249 DOI: 10.1371/journal.pntd.0000249

Cite This Page:

Public Library of Science. "Tamoxifen Might Be Effective In The Treatment Of Leishmania Amazonensis Infections." ScienceDaily. ScienceDaily, 10 June 2008. <www.sciencedaily.com/releases/2008/06/080610212419.htm>.
Public Library of Science. (2008, June 10). Tamoxifen Might Be Effective In The Treatment Of Leishmania Amazonensis Infections. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2008/06/080610212419.htm
Public Library of Science. "Tamoxifen Might Be Effective In The Treatment Of Leishmania Amazonensis Infections." ScienceDaily. www.sciencedaily.com/releases/2008/06/080610212419.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) — As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) — Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) — Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) — Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins