Featured Research

from universities, journals, and other organizations

Low Thyroid Function Common In Chronic Kidney Disease

Date:
June 11, 2008
Source:
American Society of Nephrology
Summary:
Many patients with chronic kidney disease have mild reductions in thyroid function, or subclinical hypothyroidism -- a condition that becomes more common as kidney function declines.

Many patients with chronic kidney disease (CKD) have mild reductions in thyroid function, or subclinical hypothyroidism--a condition that becomes more common as kidney function declines, according to a new study.

Related Articles


"Although no recommendations are available regarding the treatment of mild abnormalities of thyroid hormone levels in patients with CKD not requiring dialysis, these abnormalities could represent a risk factor for cardiovascular disease and might also be implicated in kidney disease progression," comments lead authors Dr. Michel Chonchol of University of Colorado Health Sciences Center and Dr. Giovanni Targher of University of Verona, Italy.

The researchers analyzed routine blood test results in more than 3,000 patients with CKD who were not receiving dialysis. Patients with CKD have loss of kidney function that, in many cases, progresses to end-stage renal disease (ESRD)--permanent loss of kidney function requiring dialysis or transplantation.

Overall, 9.5 percent of patients with CKD had subclinical hypothyroidism. This means reductions in thyroid hormone levels that are detected on blood tests with no abnormal signs or symptoms.

The lower the patients' kidney function, the higher their risk of subclinical hypothyroidism. Seven percent of patients with mild CKD had low thyroid function, compared to 18 percent of those with moderate CKD. After adjustment for other factors, patients with moderate CKD were 73 percent more likely to have subclinical hypothyroidism.

As laboratory tests become more sophisticated, the ability to detect subtle changes in thyroid function has improved. Regardless of the cause, subclinical hypothyroidism is linked to an increased risk of cardiovascular disease and reduced heart function. Patients with CKD are at greatly increased risk of cardiovascular disease.

Subclinical hypothyroidism is common, especially among older adults; lab tests show low thyroid function in four to 10 percent of the general population. Although increased rates of thyroid abnormalities have been reported in patients with ESRD, the new study is the first to show an increased rate of subclinical hypothyroidism in CKD patients not requiring chronic dialysis.

The nature and consequences of the link between CKD and low thyroid function are not yet clear. When hypothyroidism becomes more severe, it can cause reduced heart function, which can lead to progressively worsening kidney function. Thus the presence of subclinical hypothyroidism in patients with CKD might be a risk factor for both cardiovascular disease and progressive kidney disease.

Because of the lack of follow-up data, the study cannot determine whether there is any causal relationship between subclinical hypothyroidism and CKD. "Further studies should evaluate if mild elevations of the thyroid hormone are harmful for patients with kidney disease and explore the possibility of treating mild abnormalities of thyroid function with thyroid hormone replacement," according to Drs. Chonchol and Targher.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dr. Michel Chonchol, Dr. Giovanni Targher et al. Prevalence of Subclinical Hypothyroidism in Patients with Chronic Kidney Disease. Clinical Journal of the American Society of Nephrology, September 2008

Cite This Page:

American Society of Nephrology. "Low Thyroid Function Common In Chronic Kidney Disease." ScienceDaily. ScienceDaily, 11 June 2008. <www.sciencedaily.com/releases/2008/06/080611135120.htm>.
American Society of Nephrology. (2008, June 11). Low Thyroid Function Common In Chronic Kidney Disease. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2008/06/080611135120.htm
American Society of Nephrology. "Low Thyroid Function Common In Chronic Kidney Disease." ScienceDaily. www.sciencedaily.com/releases/2008/06/080611135120.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins