Featured Research

from universities, journals, and other organizations

Low Thyroid Function Common In Chronic Kidney Disease

Date:
June 11, 2008
Source:
American Society of Nephrology
Summary:
Many patients with chronic kidney disease have mild reductions in thyroid function, or subclinical hypothyroidism -- a condition that becomes more common as kidney function declines.

Many patients with chronic kidney disease (CKD) have mild reductions in thyroid function, or subclinical hypothyroidism--a condition that becomes more common as kidney function declines, according to a new study.

Related Articles


"Although no recommendations are available regarding the treatment of mild abnormalities of thyroid hormone levels in patients with CKD not requiring dialysis, these abnormalities could represent a risk factor for cardiovascular disease and might also be implicated in kidney disease progression," comments lead authors Dr. Michel Chonchol of University of Colorado Health Sciences Center and Dr. Giovanni Targher of University of Verona, Italy.

The researchers analyzed routine blood test results in more than 3,000 patients with CKD who were not receiving dialysis. Patients with CKD have loss of kidney function that, in many cases, progresses to end-stage renal disease (ESRD)--permanent loss of kidney function requiring dialysis or transplantation.

Overall, 9.5 percent of patients with CKD had subclinical hypothyroidism. This means reductions in thyroid hormone levels that are detected on blood tests with no abnormal signs or symptoms.

The lower the patients' kidney function, the higher their risk of subclinical hypothyroidism. Seven percent of patients with mild CKD had low thyroid function, compared to 18 percent of those with moderate CKD. After adjustment for other factors, patients with moderate CKD were 73 percent more likely to have subclinical hypothyroidism.

As laboratory tests become more sophisticated, the ability to detect subtle changes in thyroid function has improved. Regardless of the cause, subclinical hypothyroidism is linked to an increased risk of cardiovascular disease and reduced heart function. Patients with CKD are at greatly increased risk of cardiovascular disease.

Subclinical hypothyroidism is common, especially among older adults; lab tests show low thyroid function in four to 10 percent of the general population. Although increased rates of thyroid abnormalities have been reported in patients with ESRD, the new study is the first to show an increased rate of subclinical hypothyroidism in CKD patients not requiring chronic dialysis.

The nature and consequences of the link between CKD and low thyroid function are not yet clear. When hypothyroidism becomes more severe, it can cause reduced heart function, which can lead to progressively worsening kidney function. Thus the presence of subclinical hypothyroidism in patients with CKD might be a risk factor for both cardiovascular disease and progressive kidney disease.

Because of the lack of follow-up data, the study cannot determine whether there is any causal relationship between subclinical hypothyroidism and CKD. "Further studies should evaluate if mild elevations of the thyroid hormone are harmful for patients with kidney disease and explore the possibility of treating mild abnormalities of thyroid function with thyroid hormone replacement," according to Drs. Chonchol and Targher.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dr. Michel Chonchol, Dr. Giovanni Targher et al. Prevalence of Subclinical Hypothyroidism in Patients with Chronic Kidney Disease. Clinical Journal of the American Society of Nephrology, September 2008

Cite This Page:

American Society of Nephrology. "Low Thyroid Function Common In Chronic Kidney Disease." ScienceDaily. ScienceDaily, 11 June 2008. <www.sciencedaily.com/releases/2008/06/080611135120.htm>.
American Society of Nephrology. (2008, June 11). Low Thyroid Function Common In Chronic Kidney Disease. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2008/06/080611135120.htm
American Society of Nephrology. "Low Thyroid Function Common In Chronic Kidney Disease." ScienceDaily. www.sciencedaily.com/releases/2008/06/080611135120.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins