Featured Research

from universities, journals, and other organizations

Early Life Infections Increase The Risk Of Rheumatoid Arthritis And Juvenile Idiopathic Arthritis

Date:
June 13, 2008
Source:
European League Against Rheumatism
Summary:
Infections during the first year of life are a marker of increased risk of developing specific types of arthritis later in life, according to new research. Researchers found that infants who were hospitalized for infection before their first birthday had an increased likelihood of developing either juvenile idiopathic arthritis or adult rheumatoid arthritis in later life.

Infections during the first year of life are a marker of increased risk of developing specific types of arthritis later in life, according to new research from Sweden presented June 13 at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France.

Related Articles


Researchers from the Karolinska Institute in Sweden found that infants who were hospitalised for infection before their first birthday had an increased likelihood of developing either juvenile idiopathic arthritis (JIA) or adult rheumatoid arthritis (RA) in later life.

Investigator Dr Cecilia Carlens of The Karolinska University Hospital, Stockholm, Sweden, said: "Whilst recent research has suggested that early life infections are of importance to the maturation of the immune system in general, our analysis shows a link between perinatal infection and increased RA and JIA risk in particular, highlighting the importance of a child's formative months on his or her rheumatic health in later life."

The Swedish register-based case-control study reviewed recorded data on individuals born nationwide between 1973 and 2002, and involved 333 RA patients and 3,334 JIA patients. The analysis revealed that an increase in infections within the first 12 months is associated with an increased risk of developing JIA (odds ratio =1.9, 95% confidence interval 1.7-2.1) and sero-negative RA (odds ratio =2.6, 95% confidence interval 1.0-7.0), a distinct type of RA that is less aggressive than sero-positive RA.

However, other parts of the study suggested that perinatal charactertics, such as low birth weight (odds ratio =0.7, 95% confidence interval 0.5-1.0) and the duration of the gestational period may also affect arthritis risk in later life. A longer gestational period of over 42 weeks, emerged as a potential risk factor for developing JIA (odds ratio =1.5, 95% confidence interval 1.2-2.0).

The patient data reviewed was taken from the Swedish Inpatient Register and the Early Arthritis Register. Using the Swedish Medical Birth Register, four controls were randomly selected per case, matched by sex, year, and delivery-unit. Linkage to the Medical Birth Register and the Swedish Inpatient Register provided the necessary information on maternal-, pregnancy- and birth-characteristics, and infections during first year of life. Univariate odds ratios (OR) were calculated using conditional logistic regression.


Story Source:

The above story is based on materials provided by European League Against Rheumatism. Note: Materials may be edited for content and length.


Cite This Page:

European League Against Rheumatism. "Early Life Infections Increase The Risk Of Rheumatoid Arthritis And Juvenile Idiopathic Arthritis." ScienceDaily. ScienceDaily, 13 June 2008. <www.sciencedaily.com/releases/2008/06/080613105911.htm>.
European League Against Rheumatism. (2008, June 13). Early Life Infections Increase The Risk Of Rheumatoid Arthritis And Juvenile Idiopathic Arthritis. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2008/06/080613105911.htm
European League Against Rheumatism. "Early Life Infections Increase The Risk Of Rheumatoid Arthritis And Juvenile Idiopathic Arthritis." ScienceDaily. www.sciencedaily.com/releases/2008/06/080613105911.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins