Featured Research

from universities, journals, and other organizations

New Weapon For Attacking Tumor Invasion And Metastasis

Date:
June 21, 2008
Source:
World Journal of Gastroenterology
Summary:
Scientists have determined that AMD3100, originally developed in acquired immune deficiency syndrome treatment, could markedly inhibit spreading of colorectal cancer cells by blocking a new pair of ligands and its unique receptor. This effect differs from the usual inhibition by a conventional chemotherapic agent that is more specific to cancer cells with high metastatic potential.

A team led by Dr. Ji-Kun Li has determined that AMD3100, originally developed in acquired immune deficiency syndrome treatment, could markedly inhibit spreading of colorectal cancer cells by blocking a new pair of ligands and its unique receptor. This effect differs from the usual inhibition by a conventional chemotherapic agent that is more specific to cancer cells with high metastatic potential.

Related Articles


In vitro, AMD3100 has shown a significantly inhibitory effect on invasion and migration in colorectal cancer cell line. This effect can be further enhanced at higher concentration. This study was performed by a team led by Professor Ji-Kun Li from the Shanghai Jiao Tong University.

Colorectal cancer (CRC) is one of the main causes of cancer-related death in the world. The mortality of CRC is principally attributed to the development of liver and other metastases. It may be helpful for doctors to find a new biomarker that predicts early recurrence or distant organ metastasis. There is also a pressing need for more effective treatments for patients with advanced colorectal cancer.

In the view of the authors, their research has shown elevated CXCR4 (a new receptor on cancer cells) expression in primary CRC is associated with liver and lymph node metastasis, which prompts them to elucidate the mechanism of this phenomenon. They also found AMD3100 had significant antitumor activity through regulating pathways downstream of CXCR4 and impaired formation of tumor micro vessels and expression of invasive associated genes.

Inhibition of CRC cells survival and metastatic spread by interfering with the ligand- receptor axis has been successful in vitro. Though these data do not necessarily predict a satisfactory outcome of clinical trials, they provide a novel strategy based on this new molecule pair.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Li et al. Inhibition of CXCR4 activity with AMD3100 decreases invasion of human colorectal cancer cells in vitro. World Journal of Gastroenterology, 2008; 14 (15): 2308 DOI: 10.3748/wjg.14.2308

Cite This Page:

World Journal of Gastroenterology. "New Weapon For Attacking Tumor Invasion And Metastasis." ScienceDaily. ScienceDaily, 21 June 2008. <www.sciencedaily.com/releases/2008/06/080617093700.htm>.
World Journal of Gastroenterology. (2008, June 21). New Weapon For Attacking Tumor Invasion And Metastasis. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2008/06/080617093700.htm
World Journal of Gastroenterology. "New Weapon For Attacking Tumor Invasion And Metastasis." ScienceDaily. www.sciencedaily.com/releases/2008/06/080617093700.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Ebola Lockdown

Sierra Leone in Ebola Lockdown

Reuters - News Video Online (Mar. 27, 2015) Millions of people in Sierra Leone are urged to stay at home in a three-day lockdown to help end the country&apos;s Ebola outbreak. Paul Chapman reports. Video provided by Reuters
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins