Featured Research

from universities, journals, and other organizations

Risk Factors For Sudden Death For Adult Muscular Dystrophy Identified

Date:
June 24, 2008
Source:
Indiana University
Summary:
The largest assessment of people with adult muscular dystrophy has identified risk factors that can lead to sudden death for individuals with the most common form of this disease. Results are published in the New England Journal of Medicine.

The largest assessment of people with adult muscular dystrophy has identified risk factors that can lead to sudden death for individuals with the most common form of this disease. The results of the multicenter study, led by the Indiana University School of Medicine, are reported in the June 19 issue of the New England Journal of Medicine.

Related Articles


Neurologists and cardiologists at 23 neuromuscular disease clinics nationwide affiliated with the Muscular Dystrophy Association assessed 406 adult patients with myotonic dystrophy type 1 using clinical history, genetic assessment and electrocardiograms (ECG) to determine the risk factors that cause arrhythmias and sudden cardiac death.

"The study has prospectively identified risk factors that predict a high risk of sudden death in people with myotonic dystrophy, the most common form of muscular dystrophy that we see in adults," said the study's principal investigator and lead author William J. Groh, M.D., M.P.H., associate professor of medicine at the Indiana University School of Medicine and the Krannert Institute of Cardiology. Sudden death is defined as a death that occurs in a stable patient within one hour of the onset of symptoms.

During the 10 years of the study, 20 percent of the people enrolled died, said Dr. Groh. Of those, one-third died of sudden death likely attributable to cardiac arrhythmia.

"Patients who had significant abnormalities on their ECG were at a 3.5 times higher risk of sudden death," said Dr. Groh. "Those with atrial (upper) chamber arrthymias had a 5 times higher risk."

In the future, physicians can use these risk factors to evaluate patients with myotonic dystrophy to hopefully prevent sudden death through further evaluation including electrophysiological studies (using catheters in the heart) or by surgically implanting a cardioverter-defibrillator.

Dr. Groh said another important outcome of the study was the discovery that pacemakers, commonly used to treat some forms of arrhythmia, did not help these patients prevent sudden death.

Myotonic muscular dystrophy, an inherited disease, is characterized primarily by progressive muscle weakness and muscle wasting. It affects approximately 1 of every 8,000 people in the United States. In many muscular dystrophies, the heart muscle is adversely affected. Those heart abnormalities can be as serious and debilitating as the skeletal muscle involvement more commonly associated with muscular dystrophy.

This study was funded by Medtronic, the Muscular Dystrophy Association and the National Institutes of Health.


Story Source:

The above story is based on materials provided by Indiana University. Note: Materials may be edited for content and length.


Cite This Page:

Indiana University. "Risk Factors For Sudden Death For Adult Muscular Dystrophy Identified." ScienceDaily. ScienceDaily, 24 June 2008. <www.sciencedaily.com/releases/2008/06/080618172955.htm>.
Indiana University. (2008, June 24). Risk Factors For Sudden Death For Adult Muscular Dystrophy Identified. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2008/06/080618172955.htm
Indiana University. "Risk Factors For Sudden Death For Adult Muscular Dystrophy Identified." ScienceDaily. www.sciencedaily.com/releases/2008/06/080618172955.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins