Featured Research

from universities, journals, and other organizations

Intestinal Proteins May Be Effective Anti-Tumor Antigens

Date:
June 26, 2008
Source:
Journal of the National Cancer Institute
Summary:
Mice immunized with an intestinal protein developed fewer lung and liver metastases following injection with colon cancer cells than unvaccinated animals, according to a study in the June 24 issue of the Journal of the National Cancer Institute.

Mice immunized with an intestinal protein developed fewer lung and liver metastases following injection with colon cancer cells than unvaccinated animals, according to a study in the June 24 issue of the Journal of the National Cancer Institute.

Researchers are hindered in the development of cancer vaccines by a lack of antigens that are specific for tumors and not expressed elsewhere in the body. Immunization with antigens that are expressed elsewhere in the body raises the possibility of autoimmune complications. However, the intestinal lining and some other mucosal areas are protected from the immune system and some proteins from these immune protected sites are widely expressed on tumor cells. Therefore such proteins may be safe and effective antigens for anti-cancer vaccines.

To test this possibility, Adam Snook, Ph.D., and Scott Waldman, M.D., Ph.D., of Thomas Jefferson University in Philadelphia and colleagues immunized mice with a viral vector that expressed guanylyl cyclase C protein, which is normally only expressed in the intestinal lining and is expressed by metastatic colorectal cancer cells. The researchers injected the animals with colon cancer cells before or after immunization with guanylyl cyclase C.

The vaccinated animals developed fewer metastases in the liver and lung compared with control animals. Vaccination also prolonged overall survival, with a median of 38 days in immunized animals and 29 days in control animals. The investigators did not see any evidence of autoimmune responses.

The researchers hypothesize that the approach of using antigens from immune-restricted sites might be extended to other cancers that originate from mucosa, including cancers of the head and neck, lung, breast, vagina, and bladder.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Snook et al. Guanylyl Cyclase C-Induced Immunotherapeutic Responses Opposing Tumor Metastases Without Autoimmunity. JNCI Journal of the National Cancer Institute, 2008; DOI: 10.1093/jnci/djn178

Cite This Page:

Journal of the National Cancer Institute. "Intestinal Proteins May Be Effective Anti-Tumor Antigens." ScienceDaily. ScienceDaily, 26 June 2008. <www.sciencedaily.com/releases/2008/06/080625112211.htm>.
Journal of the National Cancer Institute. (2008, June 26). Intestinal Proteins May Be Effective Anti-Tumor Antigens. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2008/06/080625112211.htm
Journal of the National Cancer Institute. "Intestinal Proteins May Be Effective Anti-Tumor Antigens." ScienceDaily. www.sciencedaily.com/releases/2008/06/080625112211.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins