Featured Research

from universities, journals, and other organizations

Boosting Survival Of Insulin-cell Transplants For Type 1 Diabetes

Date:
July 9, 2008
Source:
American Chemical Society
Summary:
Researchers in Japan are reporting a discovery that could improve the effectiveness and expand the use of transplants of insulin-producing cells to treat diabetes. Insulin-dependent, or Type 1, diabetes affects about 800,000 people in the United States.

Scientists have developed a process that could could improve transplants of insulin-producing cells for treating diabetes. The new method prevents destruction of those cells by coating them with heparin.
Credit: Courtesy of the American Chemical Society

Researchers in Japan are reporting a discovery that could improve the effectiveness and expand the use of transplants of insulin-producing cells to treat diabetes. Insulin-dependent, or Type 1, diabetes affects about 800,000 people in the United States.

Related Articles


In the new study, Yuji Teramura and Hiroo Iwata point out that transplantation of the pancreas's insulin producing cells, so-called islets of Langerhans, is a promising experimental technique for treating patients with insulin-dependent diabetes.

However, the procedure is not sufficiently effective for many people. This is because the body destroys many of the islet cells right after transplantation in an inflammatory reaction triggered by blood clotting on the surface of the cells, the researchers say.

To address this problem, the scientists coated islet cells with a special polymer film containing heparin, an anticoagulant, or urokinase, a medication that dissolves blood clots. In laboratory studies, the researchers showed that the coatings delayed the clotting long enough to prevent the destruction that otherwise would occur immediately after transplantation.

The coatings did not affect the ability of the cells to produce insulin, the researchers add.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Teramura et al. Islets Surface Modification Prevents Blood-Mediated Inflammatory Responses. Bioconjugate Chemistry, 2008; 0 (0): 0 DOI: 10.1021/bc800064t

Cite This Page:

American Chemical Society. "Boosting Survival Of Insulin-cell Transplants For Type 1 Diabetes." ScienceDaily. ScienceDaily, 9 July 2008. <www.sciencedaily.com/releases/2008/07/080707091309.htm>.
American Chemical Society. (2008, July 9). Boosting Survival Of Insulin-cell Transplants For Type 1 Diabetes. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2008/07/080707091309.htm
American Chemical Society. "Boosting Survival Of Insulin-cell Transplants For Type 1 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2008/07/080707091309.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins