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Why Men Are More At Risk Of Diseases Caused By Blood Clots Than Women

Date:
July 14, 2008
Source:
Journal of Clinical Investigation
Summary:
Being male increases your risk of diseases caused by the inappropriate formation of a blood clot (a process known as thrombosis), such as heart attack and stroke, but the reasons for this are not completely understood. However, researchers have used a mouse model of thrombosis to shed light on this matter in the hope of facilitating the development of sex-specific treatments for thrombosis.

Being male increases your risk of diseases caused by the inappropriate formation of a blood clot (a process known as thrombosis), such as heart attack and stroke, but the reasons for this are not completely understood. However, Ethan Weiss and colleagues at the University of California, San Francisco, have used a mouse model of thrombosis to shed new light on this matter.

Thrombosis-related proteins are made in the liver, where expression of the genes containing the information needed for their generation is regulated by growth hormone (GH), which is secreted in a sex-specific manner -- males secrete GH in a pulsatile fashion, whereas females secrete GH continuously.

In this study, GH-deficient mice were protected from thrombosis in the model of disease. When female GH-deficient mice were given pulsatile GH (to mimic the manner in which GH is secreted in males) their ability to form blood clots resembled male mice.

Conversely, when male GH-deficient mice were given continuous GH (to mimic the manner in which GH is secreted in females) their ability to form blood clots resembled female mice. The authors therefore conclude that sex-specific patterns of GH release mediate the gender-associated differences observed in susceptibility to diseases caused by inappropriate thrombosis, information that they hope will be of help in the development of sex-specific treatments for thrombosis.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns. Journal of Clinical Investigation, July 10, 2008

Cite This Page:

Journal of Clinical Investigation. "Why Men Are More At Risk Of Diseases Caused By Blood Clots Than Women." ScienceDaily. ScienceDaily, 14 July 2008. <www.sciencedaily.com/releases/2008/07/080710174234.htm>.
Journal of Clinical Investigation. (2008, July 14). Why Men Are More At Risk Of Diseases Caused By Blood Clots Than Women. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2008/07/080710174234.htm
Journal of Clinical Investigation. "Why Men Are More At Risk Of Diseases Caused By Blood Clots Than Women." ScienceDaily. www.sciencedaily.com/releases/2008/07/080710174234.htm (accessed April 23, 2014).

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