Featured Research

from universities, journals, and other organizations

Defining Complications From Organophosphate Poisoning From Pesticides

Date:
July 18, 2008
Source:
Public Library of Science
Summary:
Every year, many thousands of people die as a result of poisoning by pesticides; one of the commonest types of pesticides involved are the organophosphates. Amongst individuals with organophosphate poisoning, changes in nerve transmission are seen before the development of intermediate syndrome, a complication involving muscle weakness that can lead to respiratory failure and poor outcome.

Every year, many thousands of people die as a result of poisoning by pesticides; one of the commonest types of pesticides involved are the organophosphates. A group of investigators from Sri Lanka, Australia, and the UK led by Pradeepa Jayawardane report that amongst individuals with organophosphate poisoning, changes in nerve transmission are seen before the development of intermediate syndrome (IMS), a complication involving muscle weakness that can lead to respiratory failure and poor outcome.

Prior to this work, the development of IMS in people who have accidentally or intentionally consumed organophosphates was not well understood, and no predictors of its occurrence existed. In an expert commentary on the new study, Cynthia Aaron of the Children's Hospital of Michigan, Detroit, who was not involved in the study, comments "...there has been tremendous controversy in the toxicology world concerning the true definition and existence of IMS as an isolated entity".

Pradeepa Jayawardane and colleagues studied 78 patients with organophosphate poisoning admitted to the Nuwara Eliya General Hospital and Teaching Hospital, Peradeniya in Sri Lanka. All patients were managed in the clinic according to routine procedures. In addition to standard care, the patients were evaluated using a technique called repetitive nerve stimulation, which allowed the researchers to study changes in nerve transmission.

During the study, 10 of the 78 individuals developed IMS. In these individuals, specific changes were seen in the neuromuscular transmission pattern, often before clinical signs of intermediate syndrome developed. Thirty individuals also developed muscle weakness, but not severe enough to diagnose IMS, and these individuals also developed defined changes in their neuromuscular transmission patterns.

The researchers conclude that IMS is a "spectrum disorder"; that is, the syndrome progresses over time through a series of changes which only result in respiratory failure amongst the most severe cases. The researchers also suggest that the clinical signs of IMS are preceded by changes in nerve transmission, which might therefore provide an indicator of future poor outcome.

However, before these findings can be applied directly to clinical care it is important to verify the changes in an independent group of patients. In her commentary, Aaron notes "If these distinctive electrophysiological changes are subsequently validated in further studies, they should lead to improved diagnostic and prognostic tools for clinical use in organophosphate-poisoned patients".


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jayawardane et al. The Spectrum of Intermediate Syndrome Following Acute Organophosphate Poisoning: A Prospective Cohort Study from Sri Lanka. PLoS Medicine, 2008; 5 (7): e147 DOI: 10.1371/journal.pmed.0050147

Cite This Page:

Public Library of Science. "Defining Complications From Organophosphate Poisoning From Pesticides." ScienceDaily. ScienceDaily, 18 July 2008. <www.sciencedaily.com/releases/2008/07/080714202512.htm>.
Public Library of Science. (2008, July 18). Defining Complications From Organophosphate Poisoning From Pesticides. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2008/07/080714202512.htm
Public Library of Science. "Defining Complications From Organophosphate Poisoning From Pesticides." ScienceDaily. www.sciencedaily.com/releases/2008/07/080714202512.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins