Featured Research

from universities, journals, and other organizations

Hematology: Solving Problems With Platelets

Date:
July 24, 2008
Source:
Journal of Clinical Investigation
Summary:
Individuals with very few platelets (the blood cells that regulate blood clot formation) are said to suffer from thrombocytopenia. There are many causes of thrombocytopenia, including increased destruction of platelets.

Individuals with very few platelets (the blood cells that regulate blood clot formation) are said to suffer from thrombocytopenia. There are many causes of thrombocytopenia, including increased destruction of platelets.

Related Articles


New data, generated by two independent groups, have provided clinically relevant insight into two forms of thrombocytopenia caused by increased platelet destruction — immune thrombocytopenic purpura (ITP) and fetomaternal alloimmune thrombocytopenia (FMAIT). The importance of these studies for the development of new therapeutics is discussed in an accompany commentary by Bethan Psaila and James Bussel, at Weill Cornell Medical College of Cornell University, New York.

In the first study, Masataka Kuwana and colleagues, at Keio University School of Medicine, Japan, set out to understand why platelet numbers return to nearly normal levels in about 50% of individuals with ITP who are also infected with the bacterium Helicobacter pylori after they have been treated with antibiotics to clear their H. pylori infection. It was found that immune cells known as monocytes (which are involved in the destruction of platelets through their ability to take up and degrade antibody coated platelets via activating Fc receptors) exhibited characteristics of activated cells before the H. pylori infection was eradicated.

This included high levels of activating Fc-gamma receptors and low levels of an inhibitory Fc-gamma receptor. Upon H. pylori eradication levels of the activating Fc-gamma receptors decreased and levels of the inhibitory receptor increased. The authors therefore conclude that H. pylori eradication dampens the activation status of monocytes such that their Fc-gamma repertoire favors uptake and destruction of platelets and that this is reversed upon H. pylori eradication.

In the second study, Cedric Ghevaert and colleagues, at NHS Blood and Transplant, United Kingdom, developed an approach to manipulate the interaction between antibody coated platelets and activating Fc-gamma receptors to decrease monocyte uptake and destruction of platelets. In FMAIT, mothers generate antibodies that bind to a molecule (HPA-1a) on the platelets of their fetus such that they are taken up by monocytes and destroyed.

The authors developed a molecule that binds HPA-1a in place of the mother's antibodies when analyzed in vitro. Further in vitro and mouse studies indicated that this molecule dramatically decreased platelet destruction, leading to the suggestion that this approach be evaluated in human clinical studies.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Helicobacter pylori eradication shifts monocyte Fc-gamma receptor balance toward inhibitory Fc-gamma-RIIB in immune thrombocytopenic purpura patients. Journal of Clinical Investigation, July 25, 2008

Cite This Page:

Journal of Clinical Investigation. "Hematology: Solving Problems With Platelets." ScienceDaily. ScienceDaily, 24 July 2008. <www.sciencedaily.com/releases/2008/07/080724190509.htm>.
Journal of Clinical Investigation. (2008, July 24). Hematology: Solving Problems With Platelets. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2008/07/080724190509.htm
Journal of Clinical Investigation. "Hematology: Solving Problems With Platelets." ScienceDaily. www.sciencedaily.com/releases/2008/07/080724190509.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins