Featured Research

from universities, journals, and other organizations

Cartilage That Repairs Itself? New Research Reveals Important Clues

Date:
August 1, 2008
Source:
Oregon Health & Science University
Summary:
A strain of mice with the natural ability to repair damaged cartilage may one day lead to significant improvements in treatment of human knee, shoulder and hip injuries. Researchers have discovered males from a strain of mice called MRL/MpJ have the innate ability to repair their own knee cartilage.

A strain of mice with the natural ability to repair damaged cartilage may one day lead to significant improvements in treatment of human knee, shoulder and hip injuries.

Researchers at Oregon Health & Science University have discovered males from a strain of mice called MRL/MpJ have the innate ability to repair their own knee cartilage. "We think there is something special about these mice," said Jamie Fitzgerald, Ph.D., assistant professor of orthopedics and rehabilitation in the OHSU School of Medicine. "They have the ability to regenerate cartilage."

"Knee pain is one of the most common musculoskeletal complaints that bring people to their doctor," Fitzgerald said. Cartilage is a key culprit. "Human cartilage injuries heal poorly and can lead to cartilage degeneration and osteoarthritis. This is an enormous clinical problem. It is estimated that one quarter of the adult population will have some kind of arthritis by 2020."

Knee injuries are a significant issue for professional athletes. The National Football League Charities provided the initial grant to launch the study. "Cartilage injuries can be career-ending for football players," Fitzgerald said.

Greg Oden missed his rookie season with the Blazers because of a cartilage injury. Although it's not his primary injury, champion golfer Tiger Woods was sidelined for two months this spring after surgery to deal with damaged cartilage in his left knee.

Fitzgerald and his fellow OHSU researchers Andrea Herzka, M.D., and Cathleen Rich studied knee injuries in 150 mice. Three months after the cartilage in their knees was damaged, male MRL mice had replaced a significant amount of the injured tissue with healthy cartilage. The results of their study were recently published in Osteoarthritis and Cartilage.

Chris Little, director of the Raymond Purves Bone and Joint Research Laboratories in Sydney, Australia, and one of the scientists involved in the project, says the finding is significant for human health. "The research we have published is an early, but important step in unraveling the important pathways that will facilitate development of new treatments."

The next step is understanding why these mice are able to restore the cartilage in their knees. "If we can identify what genes or proteins are necessary for cartilage to heal, we can work toward finding similar genes and proteins in humans," Herzka says. An actual treatment, however, "is many years away."

Fitzgerald became interested in studying the MRL strain of mice in 2005 while working at the Murdoch Childrens Research Institute in Melbourne, Australia. His work followed the observation that MRL mice had the ability to heal ear wounds without scarring, including replacing cartilage, hair follicles, skin and blood vessels. Little helped design the experiments and taught Fitzgerald and the OHSU team surgical techniques used in the effort.


Story Source:

The above story is based on materials provided by Oregon Health & Science University. Note: Materials may be edited for content and length.


Cite This Page:

Oregon Health & Science University. "Cartilage That Repairs Itself? New Research Reveals Important Clues." ScienceDaily. ScienceDaily, 1 August 2008. <www.sciencedaily.com/releases/2008/07/080730175520.htm>.
Oregon Health & Science University. (2008, August 1). Cartilage That Repairs Itself? New Research Reveals Important Clues. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2008/07/080730175520.htm
Oregon Health & Science University. "Cartilage That Repairs Itself? New Research Reveals Important Clues." ScienceDaily. www.sciencedaily.com/releases/2008/07/080730175520.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins