Featured Research

from universities, journals, and other organizations

Proton Pump Inhibitors Increase Risk Of Bone Fractures, Study Finds

Date:
August 12, 2008
Source:
Canadian Medical Association Journal
Summary:
Patients who use proton pump inhibitors for seven or more years to treat reflux, peptic ulcers and other conditions are at greater risk of osteoporosis-related fractures, according to this large observational study published in CMAJ.

Patients who use proton pump inhibitors for 7 or more years to treat reflux, peptic ulcers and other conditions are at greater risk of osteoporosis-related fractures, according to this large observational study of 15,792 patients published in CMAJ.

Related Articles


There is specifically an increased risk of hip fracture after 5 years of continuous exposure and an increased risk of any fracture after 7 years continuous exposure. Short-term exposure did not appear to increase risk of fractures.

Proton pump inhibitors — a class of drugs commonly prescribed to control and prevent symptoms and complications of peptic ulcer disease and GERD (reflux) — are widely used by patients for many years.

The study looked at people aged 50 and older who had hip, spinal, or wrist fractures and were matched by a control group with no history of hip, spinal or wrist fractures.

The use of proton pump inhibitors has increased in recent years and use is often of indefinite duration.

"These factors may promote the long-term use of proton pump inhibitors, leaving patients at increased risk of osteoporosis-related fractures," write Dr. Laura Targownik and coauthors.

In a related commentary, Drs. Brent Richards and David Goltzman comment that three large administrative database studies have found proton pump inhibitors increase fracture risk. They caution that both the physician and patient should together weigh the risks and benefits of the long-term use of these drugs.


Story Source:

The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Journal References:

  1. Laura E. Targownik MD MSHS, Lisa M. Lix PhD, Colleen J. Metge PhD, Heather J. Prior MSc, Stella Leung MSc, William D. Leslie MD. Use of proton pump inhibitors and risk of osteoporosis-related fractures. CMAJ, 2008; 179 (4) DOI: 10.1503/cmaj.071330
  2. J. Brent Richards, MD and David Goltzman, MD. Proton pump inhibitors: balancing the benefits and potential fracture risks. CMAJ, 2008; 179: 306-307 DOI: 10.150/cmaj.080873

Cite This Page:

Canadian Medical Association Journal. "Proton Pump Inhibitors Increase Risk Of Bone Fractures, Study Finds." ScienceDaily. ScienceDaily, 12 August 2008. <www.sciencedaily.com/releases/2008/08/080811195303.htm>.
Canadian Medical Association Journal. (2008, August 12). Proton Pump Inhibitors Increase Risk Of Bone Fractures, Study Finds. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2008/08/080811195303.htm
Canadian Medical Association Journal. "Proton Pump Inhibitors Increase Risk Of Bone Fractures, Study Finds." ScienceDaily. www.sciencedaily.com/releases/2008/08/080811195303.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins