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PET Scans May Help Assess Presence Of Brain Plaques Related To Alzheimer's Disease

Date:
August 12, 2008
Source:
JAMA and Archives Journals
Summary:
A type of positron emission tomography scanning may be useful in a noninvasive assessment of the formation of Alzheimer's disease-related plaques in the brain, according to small study posted online today that will appear in the October 2008 print issue of Archives of Neurology, one of the JAMA/Archives journals.

A type of positron emission tomography (PET) scanning may be useful in a non-invasive assessment of the formation of Alzheimer's disease–related plaques in the brain, according to small study posted online today that will appear in the October 2008 print issue of Archives of Neurology, one of the JAMA/Archives journals.

Plaques in the brain made of beta-amyloid and other compounds are considered hallmarks of the development of Alzheimer's disease, according to background information in the article. Currently, the only reliable way to assess the aggregation of these compounds in the brain is through analyzing brain tissue samples obtained during life or autopsy after death—"a major methodological obstacle considering clinical drug trials of early Alzheimer's disease," the authors note.

Ville Leinonen, M.D., Ph.D., of the University of Kuopio, Finland, and colleagues studied 10 patients without severe dementia who had undergone a biopsy of their frontal cortex because they were suspected of having normal-pressure hydrocephalus, an abnormal increase of cerebrospinal fluid in the brain. Cognitive impairment is a symptom of both Alzheimer's disease and normal-pressure hydrocephalus, and 22 percent to 42 percent of patients with symptoms of normal-pressure hydrocephalus have brain lesions characteristic of Alzheimer's disease.

Among the participants, six had beta-amyloid plaques in their tissue samples, while four displayed no Alzheimer's disease–related brain changes. The patients were injected with a marker known as carbon 11–labeled Pittsburgh Compound B ([11C]PiB) and then underwent a 90-minute PET scan.

Results of the scan indicated that patients who had beta-amyloid plaques in their brain biopsy specimen displayed a higher uptake of [11C]PiB in certain brain areas as compared with those who did not have such accumulations.

"This study supports the use of [11C]PiB PET in the evaluation of beta-amyloid deposition in, for example, mild cognitive impairment, Alzheimer's disease or normal-pressure hydrocephalus," the authors write. "Large and prospective studies are required to verify whether [11C]PiB PET will become a tool in diagnosing Alzheimer's disease. Another potential use of [11C]PiB would be the quantitative monitoring of beta-amyloid deposits in the brain in subjects under treatment in pharmaceutical trials of early Alzheimer's disease targeting amyloid accumulation."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Leinonen et al. Assessment of %u03B2-Amyloid in a Frontal Cortical Brain Biopsy Specimen and by Positron Emission Tomography With Carbon 11%u2013Labeled Pittsburgh Compound B. Arch Neurol, 2008; 65(10) [link]

Cite This Page:

JAMA and Archives Journals. "PET Scans May Help Assess Presence Of Brain Plaques Related To Alzheimer's Disease." ScienceDaily. ScienceDaily, 12 August 2008. <www.sciencedaily.com/releases/2008/08/080811195639.htm>.
JAMA and Archives Journals. (2008, August 12). PET Scans May Help Assess Presence Of Brain Plaques Related To Alzheimer's Disease. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2008/08/080811195639.htm
JAMA and Archives Journals. "PET Scans May Help Assess Presence Of Brain Plaques Related To Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2008/08/080811195639.htm (accessed September 1, 2014).

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