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Greater Response To Placebo In Children Than In Adults

Date:
August 12, 2008
Source:
Public Library of Science
Summary:
In a systematic review of antiepileptic drugs, researchers show that children with drug-resistant partial epilepsy enrolled in trials seem to have a greater response to placebo than adults enrolled in such trials. This finding is an important factor to consider when designing drug trials to be carried out in children with epilepsy.
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FULL STORY

In a systematic review of antiepileptic drugs, Philippe Ryvlin (of the Hospices Civils de Lyon, France) and colleagues show that children with drug-resistant partial epilepsy enrolled in trials seem to have a greater response to placebo than adults enrolled in such trials.

This finding is an important factor to consider when designing drug trials to be carried out in children with epilepsy.

These findings are discussed by Terry Klassen, from the University of Alberta, and his colleagues – who were not involved in the research. Klassen and colleagues comment on the "relatively weak evidence base informing medical care in children compared with adults".

They argue that there is a pressing need for more clinical trials research in children, but caution that such studies must be carefully designed and reported in order to provide valid results.


Story Source:

The above post is reprinted from materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rheims S, Cucherat M, Arzimanoglou A, Ryvlin P. Greater response to placebo in children than in adults: A systematic review and meta-analysis in drugresistant partial epilepsy. PLoS Med, 5(8): e166

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Public Library of Science. "Greater Response To Placebo In Children Than In Adults." ScienceDaily. ScienceDaily, 12 August 2008. <www.sciencedaily.com/releases/2008/08/080811215907.htm>.
Public Library of Science. (2008, August 12). Greater Response To Placebo In Children Than In Adults. ScienceDaily. Retrieved August 27, 2015 from www.sciencedaily.com/releases/2008/08/080811215907.htm
Public Library of Science. "Greater Response To Placebo In Children Than In Adults." ScienceDaily. www.sciencedaily.com/releases/2008/08/080811215907.htm (accessed August 27, 2015).

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