Featured Research

from universities, journals, and other organizations

Breast Cancer Patients Still Have Risk Of Relapse After 5 Years Of Systemic Therapy

Date:
August 13, 2008
Source:
Journal of the National Cancer Institute
Summary:
Breast cancer survivors continue to have a substantial risk of disease recurrence after five years of systemic therapy, according to a study in the Journal of the National Cancer Institute. Among breast cancer patients who were cancer-free five years after initiating systemic therapy, 89 percent remained recurrence-free at five years (approximately 10 years after a woman's initial diagnosis) and 80 percent remained recurrence free at 10 years (approximately 15 years after diagnosis).

Breast cancer survivors continue to have a substantial risk of disease recurrence after five years of systemic therapy, according to a study published in the August 12 online issue of the Journal of the National Cancer Institute.

Among breast cancer patients who were cancer-free five years after initiating systemic therapy, 89 percent remained recurrence-free at five years (approximately 10 years after a woman's initial diagnosis) and 80 percent remained recurrence free at 10 years (approximately 15 years after diagnosis).

Women who receive chemotherapy, hormone therapy, or both, in addition to surgery, have a higher rate of relapse-free survival than women who do not receive adjuvant or neoadjuvant therapy. However, even following systemic therapy, breast cancer survivors remain at risk for relapse. Few studies have evaluated the magnitude of that risk or the patient and tumor characteristics that are associated with disease recurrence.

In the current study, Abenaa Brewster, M.D., of the University of Texas M. D. Anderson Cancer Center in Houston and colleagues examined the recurrence rate in 2,838 breast cancer patients who had been treated between 1985 and 2001 at the cancer center and were included in the center's tumor registry. To determine the magnitude of residual risk following adjuvant therapy, which might include five years of hormone therapy, the researchers looked at what happened to the women five years after the start of treatment.

After a median follow-up period of 28 months, 216 women developed recurrent disease. The five-year risk of relapse for women with stage I disease was 7 percent, 11 percent for women with stage II disease, and 13 percent for women with stage III disease. Tumor grade, hormone receptor status, and endocrine therapy were all statistically significantly associated with risk of recurrence.

The increased risk of disease recurrence after five years of therapy for women with hormone receptor positive cancer points to an area of unmet clinical need. While there are risk-reduction options for postmenopausal women who have completed five years of tamoxifen therapy, none exist for premenopausal women. New strategies need to be developed for these women to further reduce their risk.

"In conclusion, this study demonstrates that patients with early stage breast cancer who are disease free at five years after [adjuvant systemic therapy] have a substantially increased residual risk of recurrence," the authors write.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Brewster et al. Residual Risk of Breast Cancer Recurrence 5 Years After Adjuvant Therapy. JNCI Journal of the National Cancer Institute, 2008; DOI: 10.1093/jnci/djn233

Cite This Page:

Journal of the National Cancer Institute. "Breast Cancer Patients Still Have Risk Of Relapse After 5 Years Of Systemic Therapy." ScienceDaily. ScienceDaily, 13 August 2008. <www.sciencedaily.com/releases/2008/08/080812135503.htm>.
Journal of the National Cancer Institute. (2008, August 13). Breast Cancer Patients Still Have Risk Of Relapse After 5 Years Of Systemic Therapy. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/08/080812135503.htm
Journal of the National Cancer Institute. "Breast Cancer Patients Still Have Risk Of Relapse After 5 Years Of Systemic Therapy." ScienceDaily. www.sciencedaily.com/releases/2008/08/080812135503.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins