Featured Research

from universities, journals, and other organizations

How Cancer Cells Come Unstuck And Spread

Date:
August 25, 2008
Source:
University of Bath
Summary:
Scientists have started a three-year study into the junctions that hold cells together, giving insight into how cancer cells can break off and spread to other parts of the body.

Photo of kidney cells with an experimental cell in green and junctions on cell surface in red.
Credit: Image courtesy of University of Bath

Scientists in the Department of Biology & Biochemistry at the University of Bath have started a three year study into the junctions that hold cells together, giving insight into how cancer cells can break off and spread to other parts of the body.

Cancer affects one in three people at some point in their lives, with most cancer deaths being caused by the development of secondary tumours in other parts of the body. This research, funded by leading medical charity Cancer Research UK, could help scientists better understand what causes cancer to spread and may suggest new ways it could be treated in the future.

Normal cells are held together by junctions on the cell surface, but in some cancers these junctions are lost. This makes the cancerous cells more likely to break off and spread tumours to other parts of the body. Dr Andrew Chalmers and Dr Paul Whitley, both lecturers from the Department of Biology & Biochemistry, are studying how a group of proteins called ESCRTs are involved in the loss of these junctions in kidney and intestine cells.

“ESCRTs are like the recycling units of the cell; they oversee the constant intake, break down and replenishing of junctions on the cell surface,” explained Dr Chalmers.

“In a cancer cell where ESCRTs are damaged, the junctions may not be restored properly; this can cause cells to separate and migrate to form secondary tumours in other parts of the body.

“Previous studies have shown a link between ESCRTs and the loss of junctions in cells of fruit flies, so we want to see whether this is also true in humans.”

During this three year project, the researchers plan to block ESCRTs in cells grown in the lab to see the effects on the junctions. They will also be looking at whether mutations of ESCRTs are more common in certain types of cancer.

Dr Paul Whitley added: “This work should tell us more about the role of ESCRTs in cancer and provide possible new targets for therapy in the future.”


Story Source:

The above story is based on materials provided by University of Bath. Note: Materials may be edited for content and length.


Cite This Page:

University of Bath. "How Cancer Cells Come Unstuck And Spread." ScienceDaily. ScienceDaily, 25 August 2008. <www.sciencedaily.com/releases/2008/08/080821110414.htm>.
University of Bath. (2008, August 25). How Cancer Cells Come Unstuck And Spread. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2008/08/080821110414.htm
University of Bath. "How Cancer Cells Come Unstuck And Spread." ScienceDaily. www.sciencedaily.com/releases/2008/08/080821110414.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins