Featured Research

from universities, journals, and other organizations

Drug-radiation Combo May Help Shrink Established Tumors

Date:
August 26, 2008
Source:
Journal of Experimental Medicine
Summary:
Researchers may be closer to understanding why anti-cancer drugs such as Ipilimumab, which boost the tumor-killing power of immune cells, haven't fared well in clinical trials. The new study, which describes a way to enhance the ability of these drugs to shrink well-established tumors, will be published online on Aug. 25 in the Journal of Experimental Medicine.

Researchers may be closer to understanding why anti-cancer drugs such as Ipilimumab, which boost the tumor-killing power of immune cells, haven't fared well in clinical trials. The new study, which describes a way to enhance the ability of these drugs to shrink well-established tumors, will be published online on August 25th in the Journal of Experimental Medicine.

The immune system's tumor-fighting T cells work best when maximally activated. Scientists have achieved this by blocking molecules that dampen the cells' activation, or by removing a population of regulatory T cells that block the killing ability of tumor-specific T cells. But neither approach has worked well in patients with established tumors.

Combining these two approaches in mice, the new study shows, caused small tumors to shrink but had no effect on large tumors. This finding suggested that some quality of large tumors makes them resistant to T cell killing.

Indeed, the blood vessels around large tumors lacked proteins required for killer T cells to crawl out of the circulation and into the tumor. Combining the T cell-boosting treatment with radiation therapy—which has been shown to increase the expression of these vessel proteins—was effective in shrinking large tumors. It remains to be seen whether combining radiation therapy with T cell-boosting drugs will be effective in humans.


Story Source:

The above story is based on materials provided by Journal of Experimental Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Experimental Medicine. "Drug-radiation Combo May Help Shrink Established Tumors." ScienceDaily. ScienceDaily, 26 August 2008. <www.sciencedaily.com/releases/2008/08/080825103519.htm>.
Journal of Experimental Medicine. (2008, August 26). Drug-radiation Combo May Help Shrink Established Tumors. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2008/08/080825103519.htm
Journal of Experimental Medicine. "Drug-radiation Combo May Help Shrink Established Tumors." ScienceDaily. www.sciencedaily.com/releases/2008/08/080825103519.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins