Featured Research

from universities, journals, and other organizations

Hearing Restoration May Be Possible With Cochlear Repair After Transplant Of Human Cord Blood Cells

Date:
September 4, 2008
Source:
Cell Transplantation: The Regenerative Medicine Journal
Summary:
Hearing loss due to cochlear damage may be repaired by transplanting human umbilical cord hematopoietic stem cells. This study, using animal models of chemical and auditory cochlear damage, found that when transplanted stem cells migrated to the damaged area, "surprisingly few" transplanted cells were necessary to help repair sensory hair cells and neurons. Researchers say transplanting umbilical cord stem cells provides hope for the repair of human hearing impairments rising from cochlear damage.

According to an Italian research team publishing their findings in the current issue of Cell Transplantation, hearing loss due to cochlear damage may be repaired by transplantation of human umbilical cord hematopoietic stem cells (HSC) since they show that a small number migrated to the damaged cochlea and repaired sensory hair cells and neurons.

Related Articles


For their study, the team used animal models in which permanent hearing loss had been induced by intense noise, chemical toxicity or both. Cochlear regeneration was only observed in animal groups that received HSC transplants.

Researchers used sensitive tracing methods to determine if the transplanted cells were capable of migrating to the cochlea and evaluated whether the cells could contribute to regenerating neurons and sensory tissue in the cochlea.

"Our findings show dramatic repair of damage with surprisingly few human-derived cells having migrated to the cochlea," said Roberto P. Revoltella, MD, PhD, lead author of the study. "A fraction of circulating HSC fused with resident cells, generating hybrids, yet the administration of HSC appeared to be correlated with tissue regeneration and repair as the cochlea in non-transplanted mice remained seriously damaged."

Results also showed that cochlear regeneration was less in the transplanted group deafened by noise rather than chemicals, implying that damage was more severe when induced by noise. Regenerative effects were greater in mice injected with a higher number of HSC. They also found that regeneration of cochlear tissues improved as time passed.

According to Revoltella, their results suggest the possibility of an "emerging strategy for inner ear rehabilitation….providing conditions for the resumption of deafened cochlea."

"This study provides hope for a potential treatment for the repair of hearing impairments, particularly those arising as a consequence of cochlear damage," said David Eve, PhD, at the University of South Florida Health, and associate editor of Cell Transplantation.

The editorial offices for CELL TRANSPLANTATION are at the Center of Excellence for Aging and Brain Repair, College of Medicine, the University of South Florida.


Story Source:

The above story is based on materials provided by Cell Transplantation: The Regenerative Medicine Journal. Note: Materials may be edited for content and length.


Cite This Page:

Cell Transplantation: The Regenerative Medicine Journal. "Hearing Restoration May Be Possible With Cochlear Repair After Transplant Of Human Cord Blood Cells." ScienceDaily. ScienceDaily, 4 September 2008. <www.sciencedaily.com/releases/2008/09/080903134211.htm>.
Cell Transplantation: The Regenerative Medicine Journal. (2008, September 4). Hearing Restoration May Be Possible With Cochlear Repair After Transplant Of Human Cord Blood Cells. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2008/09/080903134211.htm
Cell Transplantation: The Regenerative Medicine Journal. "Hearing Restoration May Be Possible With Cochlear Repair After Transplant Of Human Cord Blood Cells." ScienceDaily. www.sciencedaily.com/releases/2008/09/080903134211.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins