Featured Research

from universities, journals, and other organizations

New Methods Identify And Manipulate 'Newborn' Cells In Animal Model Of Parkinson's Disease

Date:
September 4, 2008
Source:
Cedars-Sinai Medical Center
Summary:
Researchers in the United States and Sweden used an engineered virus to deliver a protein that glows green when exposed to blue light (green fluorescent protein) into newborn cells of the striatum in an animal model of Parkinson's disease.

When cells in the brain are lost through disease or injury, neighboring cells begin to divide and multiply, but only a few areas in the brain are able to produce new neurons. Patients with Parkinson's disease suffer degeneration of certain neurons that reside in an area of the brain called the substantia nigra and project into the striatum. Many of the newborn cells in these areas have not been well described because of limitations of methods used to characterize them.

A research team from Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute and Lund University in Sweden used an engineered virus to deliver a protein that glows green when exposed to blue light (green fluorescent protein) into newborn cells of the striatum in an animal model (rats) of Parkinson's disease. This revealed that no neurons are formed; most of the cells appear to be glial (structural) cells.

To determine if the newborn cells could be manipulated to generate neurons, the researchers delivered into the cells two genes (neurogenin2 and noggin) that are involved in the genesis of neurons. Neither gene had any effect on the ability of newborn striatal cells to form new neurons, but the insertion of noggin greatly increased the number of oligodendrocytes, cells that support neurons.

Dwain Morris-Irvin, Ph.D., a research scientist at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute and Lund University, is available to describe how scientists are using green fluorescent protein and other new approaches in their effort to find cures for Parkinson's disease and other neurodegenerative brain disorders. Morris-Irvin is the first and corresponding author of a recent cover article in Neurobiology of Disease.

"These results may have great potential for studying the effects of viral gene delivery in the attempt to generate new cells for cell replacement therapy in neurodegenerative diseases or for brain repair after injury," Morris-Irvin said. "The success of a 'self-repair' strategy depends on the continued growth of our understanding of complex signaling patterns governing the development of these newborn cells."


Story Source:

The above story is based on materials provided by Cedars-Sinai Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cedars-Sinai Medical Center. "New Methods Identify And Manipulate 'Newborn' Cells In Animal Model Of Parkinson's Disease." ScienceDaily. ScienceDaily, 4 September 2008. <www.sciencedaily.com/releases/2008/09/080903172407.htm>.
Cedars-Sinai Medical Center. (2008, September 4). New Methods Identify And Manipulate 'Newborn' Cells In Animal Model Of Parkinson's Disease. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/09/080903172407.htm
Cedars-Sinai Medical Center. "New Methods Identify And Manipulate 'Newborn' Cells In Animal Model Of Parkinson's Disease." ScienceDaily. www.sciencedaily.com/releases/2008/09/080903172407.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins