Featured Research

from universities, journals, and other organizations

Potential New Drug For Cocaine Addiction And Overdose

Date:
September 16, 2008
Source:
American Chemical Society
Summary:
Chemists are reporting development of what they term the most powerful substance ever discovered for eliminating cocaine from the body, an advance that could lead to the world's first effective medicine for fighting overdoses and addictions of the illicit drug.

Chemists have developed a substance that could help fight addictions and overdoses of cocaine (like that shown in the above DEA library photo).
Credit: U.S. Drug Enforcement Administration

Chemists are reporting development of what they term the most powerful substance ever discovered for eliminating cocaine from the body, an advance that could lead to the world's first effective medicine for fighting overdoses and addictions of the illicit drug.

Their findings are scheduled for the Sept. 24 issue of the Journal of the American Chemical Society, a weekly publication.

In the new study, Chang-Guo Zhan and colleagues point out no effective anti-cocaine medication currently exists for cocaine abuse. One of the most promising approaches focuses on substances that mimic butyrylcholinesterase (BChE), a natural blood protein that helps break down and inactivate the drug, researchers say. However, natural BChE is too weak and ineffective for medical use, the researchers note.

The researchers describe design and produce the most potent, stable BChE structure ever produced. In lab studies, that form of BChE broke down, or metabolized, cocaine 2,000 times faster than the body's natural version of BChE, the scientists say, noting that reducing levels of the drug in the blood is a key to fighting overdose in humans. The substance also prevented convulsions and death when injected into mice that were given overdoses of cocaine, they note.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Potential New Drug For Cocaine Addiction And Overdose." ScienceDaily. ScienceDaily, 16 September 2008. <www.sciencedaily.com/releases/2008/09/080915164427.htm>.
American Chemical Society. (2008, September 16). Potential New Drug For Cocaine Addiction And Overdose. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/09/080915164427.htm
American Chemical Society. "Potential New Drug For Cocaine Addiction And Overdose." ScienceDaily. www.sciencedaily.com/releases/2008/09/080915164427.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins