Featured Research

from universities, journals, and other organizations

Why Kidneys From Older Donors Do Not Last As Long As Those From Younger Individuals

Date:
September 24, 2008
Source:
American Society of Nephrology
Summary:
Kidneys from older donors often do not survive long after transplantation because of certain structural dysfunctions that can occur as the kidney ages, according to a new study.

Kidneys from older donors often do not survive long after transplantation because of certain structural dysfunctions that can occur as the kidney ages, according to a new study. The findings indicate that the number of functioning glomeruli—the filtering units of the kidney—drops significantly with age, leading to a self-perpetuating injury in the rest of the kidney.

Related Articles


Thousands of individuals are on the waiting list for kidney transplants in the United States, and the average waiting time is more than three years. One response to the donor deficit has been to increase the number of transplants from older deceased donors. However, these kidneys exhibit a striking reduction in the 5-year graft survival rate. "We need to understand the process of renal senescence better in order to better select older donor organs that are likely to function well after transplantation," said Jane C.Tan, MD, of the Stanford University Medical Center in Stanford, California.

To understand the aging-related changes in the kidney that account for the shortened survival of older organs, Dr. Tan and her colleagues analyzed the structures of kidneys from 20 aging (>55 years) and 23 youthful (<40 years) deceased donors. They also looked specifically at the glomeruli of a subset of 13 aging and 12 youthful deceased donors that were taken prior to transplantation.

The investigators found a 32% depression of the glomerular filtration rate, a measure of the kidneys' ability to filter and remove waste products, in the aging vs youthful groups. In addition, the number of functioning glomeruli was profoundly depressed in older kidneys compared with younger kidneys. The authors proposed that this could lead to a "remnant kidney" phenomenon, whereby a self-perpetuating injury to the remaining kidney tissue occurs, ultimately contributing to shortened survival of the transplanted organ.

Information from this study might be useful for selecting kidneys from older donors when younger organs are not available. Kidneys with a greater number functioning glomeruli would clearly be better suited for transplantation than those with fewer glomeruli.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Glomerular Function, Structure and Number in Aging Deceased Donor Kidney Transplants. Journal of the American Society Nephrology, September 24, 2008 online, January 2009 print issue

Cite This Page:

American Society of Nephrology. "Why Kidneys From Older Donors Do Not Last As Long As Those From Younger Individuals." ScienceDaily. ScienceDaily, 24 September 2008. <www.sciencedaily.com/releases/2008/09/080924175156.htm>.
American Society of Nephrology. (2008, September 24). Why Kidneys From Older Donors Do Not Last As Long As Those From Younger Individuals. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2008/09/080924175156.htm
American Society of Nephrology. "Why Kidneys From Older Donors Do Not Last As Long As Those From Younger Individuals." ScienceDaily. www.sciencedaily.com/releases/2008/09/080924175156.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins