Featured Research

from universities, journals, and other organizations

Loss Of The Protein Target Of Lithium Disrupts Normal Mouse Embryonic Heart Development

Date:
October 3, 2008
Source:
Journal of Clinical Investigation
Summary:
One drug used to treat bipolar disorder is lithium, an inhibitor of GSK-3 proteins controversially linked to congenital heart defects. However, new data indicate that mice lacking GSK-3-beta die before birth, mostly at the late stage of embryonic development because of numerous defects in the heart. It is therefore suggested that it might be wise to exercise caution when considering whether to treat women of childbearing age with newer, more powerful GSK-3 inhibitors.

One drug used to treat bipolar disorder is lithium, an inhibitor of GSK-3 proteins controversially linked to congenital heart defects. However, new data indicate that mice lacking GSK-3-beta die before birth, mostly at the late stage of embryonic development because of numerous defects in the heart. It is therefore suggested that it might be wise to exercise caution when considering whether to treat women of childbearing age with newer, more powerful GSK-3 inhibitors.

Related Articles


Individuals with bipolar disorder are usually treated with 'mood stabilizing' drugs, one of which is lithium — an inhibitor of GSK-3 proteins.

As new drugs that are more powerful inhibitors of GSK-3 are under development despite controversial studies suggesting a link between lithium therapy and congenital heart defects, Thomas Force and colleagues, at Thomas Jefferson University, Philadelphia, set out to determine whether GSK-3 proteins are important for heart development in mice.

In the study, mice lacking GSK-3-alpha were born with a normal heart; however, mice lacking GSK-3-beta died before birth. Some of the embryos died of severe liver degeneration approximately half way through gestation, but most died at the late stages of development.

These embryos exhibited numerous defects in the heart, including thickening of the heart muscle due to increased proliferation of the heart muscle cells. The authors therefore suggest that although controversy remains as to whether lithium is teratogenic, it would be wise to exercise caution when considering whether to treat women of childbearing age with the new generation of GSK-3 inhibitors.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Deletion of GSK-3-beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. Journal of Clinical Investigation, (in press)

Cite This Page:

Journal of Clinical Investigation. "Loss Of The Protein Target Of Lithium Disrupts Normal Mouse Embryonic Heart Development." ScienceDaily. ScienceDaily, 3 October 2008. <www.sciencedaily.com/releases/2008/10/081001181308.htm>.
Journal of Clinical Investigation. (2008, October 3). Loss Of The Protein Target Of Lithium Disrupts Normal Mouse Embryonic Heart Development. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2008/10/081001181308.htm
Journal of Clinical Investigation. "Loss Of The Protein Target Of Lithium Disrupts Normal Mouse Embryonic Heart Development." ScienceDaily. www.sciencedaily.com/releases/2008/10/081001181308.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins