Featured Research

from universities, journals, and other organizations

Liver Transplant Recipients Almost Three Times More Likely To Develop Cancer

Date:
October 3, 2008
Source:
Wiley-Blackwell
Summary:
Cancer incidence is higher among liver transplant recipients in Finland compared to the general population, according to a new study.

Cancer incidence is higher among liver transplant recipients in Finland compared to the general population, according to a new study in the October issue of Liver Transplantation.

Related Articles


Transplantation, and subsequent immunosuppression which keeps rejection at bay, have long been associated with increased cancer risk. Several studies have examined the issue, but few have used a control population for comparison, and many rely on limited data. More studies are needed to reliably reveal the cancer risk pattern after transplantation, so doctors can optimize immunosuppression, cancer surveillance and risk management.

Researchers, led by Helena Isoniemi of Finland , sought to describe the cancer risk pattern in Finnish liver transplant patients, hypothesizing that the incidence of specific types of cancer would be higher among the recipients. They included all liver transplant patients from Helsinki University Central Hospital transplanted between 1982 and 2005. Using the Finnish Population Register and the national Cancer Registry, they were able to follow-up on each patient beginning at the date of transplant through the end of 2005.

Among the 540 liver transplant recipients, they found a total of 39 post-transplant de novo cancers in 36 patients. The overall standardized incidence ratio (SIR) compared to the general population was 2.59. Non-Hodgkin lymphoma, non-melanoma skin cancer and basal cell carcinoma had significantly elevated SIRs.

"The most common cancer types in our cohort were lymphoma and skin cancer," the authors report. "Non-Hodgkin lymphoma, which included four cases of post-transplant lymphoproliverative disorder, occurred more frequently in males, in patients transplanted at a younger age and soon after transplantation." By contrast, non-melanoma skin cancer was more common among older patients and those who had antibody induction therapy. Interestingly, the authors found lower cancer incidence among patients with history of acute rejections, correlating most strongly with lymphomas.

"Based on our data, one out of six liver transplant patients is estimated to develop some form of cancer by 20 years after transplantation." The authors report. "This study points out the importance of cancer surveillance after liver transplantation."

An accompanying editorial by Ashokkumar Jain of the University of Rochester et. al. reviews the Aberg et al findings alongside the rest of the literature, looking closely at patient age and duration of follow-up. Aberg and colleagues "show that the cumulative incidence of de novo cancers increased at 1, 5, 10 and 20 years of follow up from 3 percent, 5 percent, 13 percent and 16 percent respectively," Jain writes.

He also pointed out that other reports have noted a significantly increased risk of de novo oropharyngeal and lung cancers amongst liver transplant patients that smoke, which is a potentially preventable condition.

Throughout the literature, Jain and his coauthors found wide variation in the reported incidence of post transplant cancers, partly related to the length of follow up and partly related to the inclusion or exclusion of lymphoid lesions.

"The overall rate of de novo solid tumors increased with age at the time of transplant and the length of follow up; while the rate of post-transplant lympho-proliferative disorders decreased with age at the liver transplant, with a higher incidence in the first few years," they conclude.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "Liver Transplant Recipients Almost Three Times More Likely To Develop Cancer." ScienceDaily. ScienceDaily, 3 October 2008. <www.sciencedaily.com/releases/2008/10/081002172239.htm>.
Wiley-Blackwell. (2008, October 3). Liver Transplant Recipients Almost Three Times More Likely To Develop Cancer. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2008/10/081002172239.htm
Wiley-Blackwell. "Liver Transplant Recipients Almost Three Times More Likely To Develop Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/10/081002172239.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins