Featured Research

from universities, journals, and other organizations

Liver Transplant Recipients Almost Three Times More Likely To Develop Cancer

Date:
October 3, 2008
Source:
Wiley-Blackwell
Summary:
Cancer incidence is higher among liver transplant recipients in Finland compared to the general population, according to a new study.

Cancer incidence is higher among liver transplant recipients in Finland compared to the general population, according to a new study in the October issue of Liver Transplantation.

Transplantation, and subsequent immunosuppression which keeps rejection at bay, have long been associated with increased cancer risk. Several studies have examined the issue, but few have used a control population for comparison, and many rely on limited data. More studies are needed to reliably reveal the cancer risk pattern after transplantation, so doctors can optimize immunosuppression, cancer surveillance and risk management.

Researchers, led by Helena Isoniemi of Finland , sought to describe the cancer risk pattern in Finnish liver transplant patients, hypothesizing that the incidence of specific types of cancer would be higher among the recipients. They included all liver transplant patients from Helsinki University Central Hospital transplanted between 1982 and 2005. Using the Finnish Population Register and the national Cancer Registry, they were able to follow-up on each patient beginning at the date of transplant through the end of 2005.

Among the 540 liver transplant recipients, they found a total of 39 post-transplant de novo cancers in 36 patients. The overall standardized incidence ratio (SIR) compared to the general population was 2.59. Non-Hodgkin lymphoma, non-melanoma skin cancer and basal cell carcinoma had significantly elevated SIRs.

"The most common cancer types in our cohort were lymphoma and skin cancer," the authors report. "Non-Hodgkin lymphoma, which included four cases of post-transplant lymphoproliverative disorder, occurred more frequently in males, in patients transplanted at a younger age and soon after transplantation." By contrast, non-melanoma skin cancer was more common among older patients and those who had antibody induction therapy. Interestingly, the authors found lower cancer incidence among patients with history of acute rejections, correlating most strongly with lymphomas.

"Based on our data, one out of six liver transplant patients is estimated to develop some form of cancer by 20 years after transplantation." The authors report. "This study points out the importance of cancer surveillance after liver transplantation."

An accompanying editorial by Ashokkumar Jain of the University of Rochester et. al. reviews the Aberg et al findings alongside the rest of the literature, looking closely at patient age and duration of follow-up. Aberg and colleagues "show that the cumulative incidence of de novo cancers increased at 1, 5, 10 and 20 years of follow up from 3 percent, 5 percent, 13 percent and 16 percent respectively," Jain writes.

He also pointed out that other reports have noted a significantly increased risk of de novo oropharyngeal and lung cancers amongst liver transplant patients that smoke, which is a potentially preventable condition.

Throughout the literature, Jain and his coauthors found wide variation in the reported incidence of post transplant cancers, partly related to the length of follow up and partly related to the inclusion or exclusion of lymphoid lesions.

"The overall rate of de novo solid tumors increased with age at the time of transplant and the length of follow up; while the rate of post-transplant lympho-proliferative disorders decreased with age at the liver transplant, with a higher incidence in the first few years," they conclude.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "Liver Transplant Recipients Almost Three Times More Likely To Develop Cancer." ScienceDaily. ScienceDaily, 3 October 2008. <www.sciencedaily.com/releases/2008/10/081002172239.htm>.
Wiley-Blackwell. (2008, October 3). Liver Transplant Recipients Almost Three Times More Likely To Develop Cancer. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/10/081002172239.htm
Wiley-Blackwell. "Liver Transplant Recipients Almost Three Times More Likely To Develop Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/10/081002172239.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins