Featured Research

from universities, journals, and other organizations

Nicotine Linked To Breast Cancer Growth And Spread, Study Suggests

Date:
October 19, 2008
Source:
American Association for Cancer Research
Summary:
A new study suggests a possible role for nicotine in breast tumor development and metastases.

A study published in Cancer Research, a journal of the American Association for Cancer Research, suggests a possible role for nicotine in breast tumor development and metastases.

Related Articles


The study, conducted by researchers at the Beth Israel Deaconess Medical Center, is among the first to explore the effects of nicotine on mammary cells.

"Although numerous studies indicate the role of nicotine exposure in tumor promotion, little is known about the effect of nicotine on breast tumor development, especially on the metastatic process of breast cancer," said lead author Chang Yan Chen, Ph.D., M.D., at Beth Israel Deaconess Medical Center.

Through a series of in vitro tests Chen and her team of researchers determined that breast epithelial-like MCF10A cells and cancerous MCF7 cells both express several subunits of nAChR (nicotine receptor), that when bound, initiate a signaling process, potentially increasing cell growth and migration.

"The best known role of nAChR is in the nerve system," Chen said. "Although cells from various tissue origins express different subunits of nAChR, we know very little about the functions of nAChR in non-neuronal cells and tissues, in particular in mammary cells."

"We were able to determine that mammary cells express different subunits of nAChR and that nicotine, possibly through perturbing cell cycle checkpoints, potentiates tumorigenesis in mammary cancer-prone or cancer cells," Chen said.

In vivo studies confirmed these findings. When injected into the tail of a mouse the cancerous MCF7 cells migrated to the lungs.

From in vivo and in vitro studies, it indicates that nicotine is not a conventional carcinogen, but rather it combines with other yet to be determined factors to enable tumorigenesis.

"In vitro and in vivo tests showed that no metastasis occurs when the administration of nicotine alone," said Chen. "At this point we can only suggest that nicotine potentiates the growth-related process."

Chen hopes to conduct more studies, in particular under the genetic backgrounds with loss or defect of different tumor suppressors, to further explore the effects of nicotine in relation to first- and second-hand exposure, on breast cancer initiation and development.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Nicotine Linked To Breast Cancer Growth And Spread, Study Suggests." ScienceDaily. ScienceDaily, 19 October 2008. <www.sciencedaily.com/releases/2008/10/081015073938.htm>.
American Association for Cancer Research. (2008, October 19). Nicotine Linked To Breast Cancer Growth And Spread, Study Suggests. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2008/10/081015073938.htm
American Association for Cancer Research. "Nicotine Linked To Breast Cancer Growth And Spread, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/10/081015073938.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
New Hormone Could Protect Against Diabetes And Weight Gain

New Hormone Could Protect Against Diabetes And Weight Gain

Newsy (Mar. 4, 2015) A newly discovered hormone mimics the effects of exercise, protecting against diabetes and weight gain. Video provided by Newsy
Powered by NewsLook.com
Mount Everest Has a Poop Problem

Mount Everest Has a Poop Problem

Buzz60 (Mar. 4, 2015) With no bathrooms to use, climbers of Mount Everest have been leaving human waste on the mountain for years, and it&apos;s becoming a health issue. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com
The Best Tips to 'Skinny' Your Home

The Best Tips to 'Skinny' Your Home

Buzz60 (Mar. 4, 2015) If you&apos;re looking to reach your health goals this season, there are a few simple tips to help you spring clean your space and improve your nutrition. Krystin Goodwin (@krystingoodwin) has the skinny on keeping a healthy home. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins