Featured Research

from universities, journals, and other organizations

New Therapy For Heart Failure

Date:
October 15, 2008
Source:
Netherlands Organization for Scientific Research
Summary:
During heart failure the body reacts to the production of the hormone aldosterone. Too much aldosterone can stiffen and damage the muscles of the heart. Researchers have now optimized compounds that inhibit the production of this hormone and looked at their optimum dosage.

During heart failure the body reacts to the production of the hormone aldosterone. Too much aldosterone can stiffen and damage the muscles of the heart. Dutch researcher Luc Roumen has optimised compounds that inhibit the production of this hormone and looked at their optimum dosage.

The compounds were manufactured by the companies Schering-Plough and SyMO-Chem BV and a drug patent has been applied for.

Luc Roumen has developed a new therapy for the prevention of heart failure. The idea is to administer a drug that blocks the enzyme responsible for the production of aldosterone, namely cytochrome P450 11B2. The related enzyme 11B1 is involved in the production of other important hormones. Roumen searched for a highly selective drug that would only block 11B2, but not 11B1, to ensure a minimum of side effects when the drug is administered.

Computer simulation

Roumen examined the three-dimensional structure of both enzymes using computer simulations and was able to analyse the dynamic behaviour of the enzymes and a number of candidate drugs. This provided valuable information about the interactions preferred by the 11B2 enzyme. By optimising the interactions between the enzyme and a potential drug it was then possible to develop a number of very active and selective compounds. These can later be used as medicines.

Patent

The compounds developed were synthesised by the companies Schering-Plough (formerly Organon BV) and SyMO-Chem BV. The potential of the compounds was tested on cell cultures and rat models by Maastricht University. A patent application has been made for a drug that reacted positively both in cell culture and in the rat models. The results are being documented by Maastricht University and Schering-Plough.


Story Source:

The above story is based on materials provided by Netherlands Organization for Scientific Research. Note: Materials may be edited for content and length.


Cite This Page:

Netherlands Organization for Scientific Research. "New Therapy For Heart Failure." ScienceDaily. ScienceDaily, 15 October 2008. <www.sciencedaily.com/releases/2008/10/081015100037.htm>.
Netherlands Organization for Scientific Research. (2008, October 15). New Therapy For Heart Failure. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2008/10/081015100037.htm
Netherlands Organization for Scientific Research. "New Therapy For Heart Failure." ScienceDaily. www.sciencedaily.com/releases/2008/10/081015100037.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins