Featured Research

from universities, journals, and other organizations

Sun-damaged Skin Responds Well To Laser Treatment

Date:
October 24, 2008
Source:
University of Michigan Health System
Summary:
Researchers have found scientific evidence that the appearance of sun-damaged skin may be improved by treatment with a topical product that increases the skin's sensitivity to light, followed by laser therapy.

Researchers at the University of Michigan Health System Department of Dermatology have found scientific evidence that the appearance of sun-damaged skin may be improved by treatment with a topical product that increases the skin's sensitivity to light, followed by laser therapy.

In the new study, participants whose skin was sun-damaged – or photodamaged – were treated with a topical photosensitizer called 5-aminolevulinic acid (5-ALA) and then with a pulsed dye laser. This type of treatment, known as photodynamic therapy, increased collagen levels in the skin and also produced other skin changes that are known to improve its appearance.

The results also suggest that skin with the worst sun damage may respond particularly well to this treatment.

"This is new scientific evidence that photodynamic therapy may in fact be a useful tool to improve the appearance of the skin. This type of therapy has been performed in clinical practice for the past few years, but we've never had detailed molecular evidence for why it may work," says lead author Jeffrey S. Orringer, M.D., associate professor of dermatology at the U-M Health System and director of U-M's Cosmetic Dermatology and Laser Center. The study appears in the October issue of the Archives of Dermatology.

The study looked at 24 adults, ages 54 to 83, all of whom had significant photodamage on the forearm skin. They received a three-hour application of 5-ALA followed by pulsed dye laser therapy. Researchers examined biopsies taken before and at several times after the treatments, and they recorded the molecular changes in the participants' skin at various stages.

Among many other molecular changes, levels of the proteins procollagen I and procollagen III increased after treatment. For instance, one month after treatment, levels of procollagen I peaked with an increase of 2.65 times the pre-treatment levels. Procollagen III peaked one month after treatment with an increase of 3.32 times the pre-treatment levels. Other protein levels molecular markers also increased.

The study represents the latest example of U-M's human appearance research program's unraveling of the mechanisms by which popular treatments improve the appearance of the skin, Orringer notes.

The group has studied the treatment of sun-damaged skin with estrogen, the science behind wrinkle treatments, the effects of smoking on aging skin, and more.

Photodynamic therapy has been used as a treatment for precancerous lesions called actinic keratoses and for some types of skin cancer, but little scientific research has been conducted about its use in appearance-oriented dermatology.

Future studies are needed to gauge whether the improvements shown in the forearm skin in this study can be replicated on facial skin.

Authors: In addition to Orringer, authors of the paper – all from the U-M Department of Dermatology – were senior author John J. Voorhees, M.D., FRCP, Duncan and Ella Poth Distinguished Professor and chairman of the Department of Dermatology; Craig Hammerberg, Ph.D., laboratory manager; Ted Hamilton, M.S., senior research associate; Timothy M. Johnson, M.D., professor and director of the Cutaneous Surgery and Oncology Unit and the Melanoma Clinic; Sewon Kang, M.D., formerly a professor of dermatology at U-M; Dana L. Sachs, M.D., associate professor; and Gary Fisher, Ph.D., Harry Helfman Professor of Molecular Dermatology.

Funding: The study was funded by the Human Appearance Research Program (HARP) of the U-M Department of Dermatology.


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Molecular Effects of Photodynamic Therapy for Photoaging. Archives of Dermatology, Vol. 144, No. 10, October 2008

Cite This Page:

University of Michigan Health System. "Sun-damaged Skin Responds Well To Laser Treatment." ScienceDaily. ScienceDaily, 24 October 2008. <www.sciencedaily.com/releases/2008/10/081020171335.htm>.
University of Michigan Health System. (2008, October 24). Sun-damaged Skin Responds Well To Laser Treatment. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2008/10/081020171335.htm
University of Michigan Health System. "Sun-damaged Skin Responds Well To Laser Treatment." ScienceDaily. www.sciencedaily.com/releases/2008/10/081020171335.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins