Featured Research

from universities, journals, and other organizations

Gender Matching Aids Long-term Survival After Heart Transplants

Date:
November 13, 2008
Source:
American Heart Association
Summary:
Men who received heart transplants from a male donor and women who had female donors had lower chances of death than patients who received a transplant from the opposite sex, according to a new 10-year study. Pairing female patients with male donors had the greatest risk for death during the study. Researchers said heart size and perhaps differences in the immune system explain the correlation.

Gender matching between donors and recipients is important to short- and long-term survival in heart transplantation, according to a retrospective study presented at the American Heart Association’s Scientific Sessions 2008.

“Heart size would seem to be the most obvious factor; beyond that, no one knows why sex matching is important to transplant survival,” said Eric Weiss, M.D., first author of the study and a post doctoral research fellow in the Division of Cardiac Surgery at The Johns Hopkins University Medical Institutions in Baltimore, Md. “In clinical transplantation, we generally don’t assume that organs from male and female donors have inherent differences affecting long-term outcomes, but our data suggest that there are important differences which must be taken into account.”

Researchers analyzed data from the United Network of Organ Sharing (UNOS), identifying 18,240 patients who received their first orthotopic (replacing a failing organ with a healthy one) heart transplant between 1998 and 2007. In this dataset, patients were followed for 10 years, with the average follow-up time being 3.4 years.

Patients were sorted into four groups: male donor with male recipient, female donor with male recipient, male donor with female recipient, and female donor with female recipient.

Overall, 71 percent were matched by gender to their donor (77 percent of male recipients and 51 percent of female recipients). Twenty-five percent of patients died during the study.

Matching donor and recipient by gender resulted in:

  • 13 percent lower risk of graft rejection within the first year;
  • 14 percent lower rate of graft rejection over the study period;
  • 25 percent drop in 30-day death rate; and
  • 20 percent lower one-year death rate.

Statistical modeling revealed that the greatest chance for death during the study occurred when pairing a male donor with a female recipient, which made the risk of death an estimated 20 percent higher compared to a male donor with male recipient. The most successful transplants occurred between male recipients and male donors, when the cumulative chance for survival was 61 percent.

“These results fit with our hypothesis that sex matching in heart transplantation leads to improved survival rates,” said Weiss, the Irene Piccinini Investigator in Cardiac Surgery. “We hypothesized that we would see a big difference in the short-term survival — which we did, most likely because of heart-size issues — but what was interesting was the substantial difference in the long term, as well.”

More than 2,000 transplant surgeries are done each year. Almost 87.5 percent of male recipients and 85.5 percent of female recipients live for more than a year after the transplant, according to American Heart Association statistics.

“We don’t recommend that patients wait longer for a same-sex organ,” Weiss said. “Clearly receiving a heart transplant from a donor of opposite sex is preferable to severe heart failure. If equivalent donors exist for a given patient, our data suggest that picking a sex matched donor may lead to improved short- and long-term survival.”

Co-authors are: Nishant D. Patel, B.A.; Stuart D. Russell, M.D.; William A. Baumgartner, M.D.; Ashish S. Shah, M.D.; and John V. Conte, M.D. Individual author disclosures can be found on the abstract.

A Health Resources and Services Administration contract and a Ruth L. Kirschstein National Research Service Award from the National Institutes of Health funded the study.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Gender Matching Aids Long-term Survival After Heart Transplants." ScienceDaily. ScienceDaily, 13 November 2008. <www.sciencedaily.com/releases/2008/11/081112113551.htm>.
American Heart Association. (2008, November 13). Gender Matching Aids Long-term Survival After Heart Transplants. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/11/081112113551.htm
American Heart Association. "Gender Matching Aids Long-term Survival After Heart Transplants." ScienceDaily. www.sciencedaily.com/releases/2008/11/081112113551.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins