Featured Research

from universities, journals, and other organizations

Advanced Lung Cancer Patients See Improved, Progression-free Survival

Date:
November 25, 2008
Source:
American Society for Therapeutic Radiology and Oncology
Summary:
Patients with advanced non-small cell lung cancer whose disease has progressed following chemotherapy have a higher rate of tumor shrinkage and a longer interval before cancer progression when bevacizumab is added to standard second-line erlotinib therapy, according to a study presented at the 2008 Chicago Multidisciplinary Symposium in Thoracic Oncology, sponsored by ASTRO, ASCO, IASLC and the University of Chicago.

Patients with advanced non-small cell lung cancer whose disease has progressed following chemotherapy have a higher rate of tumor shrinkage and a longer interval before cancer progression when bevacizumab is added to standard second-line erlotinib therapy, according to a study presented at the 2008 Chicago Multidisciplinary Symposium in Thoracic Oncology, sponsored by ASTRO, ASCO, IASLC and the University of Chicago.

Related Articles


Bevacizumab in combination with chemotherapy and erlotinib alone have each demonstrated a significant improvement in survival when used for the treatment of patients with advanced non-small cell lung cancer. Researchers in this phase III, multicenter clinical trial were hopeful that the combination of the two agents that target different pathways would show a survival benefit.

Six hundred and thirty six patients were enrolled in the study between June 2005 and April 2008. All patients received erlotinib combined with either bevacizumab or a placebo. Neither the patients nor their doctors knew whether they were receiving bevacizumab or the placebo. The final analysis was conducted after 418 deaths.

The study found that the addition of bevacizumab to erlotinib did not improve overall survival compared to erlotinib and placebo. However, there was clear evidence of clinical activity with improvements in progression-free survival and response rate when bevacizumab was added to erlotinib compared to erlotinib alone.

“Bevacizumab and erlotinib are active agents in the treatment of advanced NSCLC. Together they improve progression free survival of patients with recurrent advanced NSCLC,” said John Hainsworth, M.D., lead author on this study and chief scientific officer at the Sarah Cannon Research Institute in Nashville. “We remain committed to exploring how survival can be improved using these agents.”

The abstract, “A Phase III, Multicenter, Placebo-controlled, Double-blind, Randomized Clinical Trial to Evaluate the Efficacy of Bevacizumab (Avastin) in Combination with Erlotinib (Tarceva) Compared with Erlotinib Alone for Treatment of Advanced Non-small Cell Lung Cancer after Failure of Standard First- line Chemotherapy (BETA),” will be presented in the plenary session on Friday, November 14.


Story Source:

The above story is based on materials provided by American Society for Therapeutic Radiology and Oncology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Therapeutic Radiology and Oncology. "Advanced Lung Cancer Patients See Improved, Progression-free Survival." ScienceDaily. ScienceDaily, 25 November 2008. <www.sciencedaily.com/releases/2008/11/081113091619.htm>.
American Society for Therapeutic Radiology and Oncology. (2008, November 25). Advanced Lung Cancer Patients See Improved, Progression-free Survival. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2008/11/081113091619.htm
American Society for Therapeutic Radiology and Oncology. "Advanced Lung Cancer Patients See Improved, Progression-free Survival." ScienceDaily. www.sciencedaily.com/releases/2008/11/081113091619.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins