Featured Research

from universities, journals, and other organizations

Common and cancer type-specific loss-of-heterozygosity in tumor stroma and epithelium of three carcinoma types associated with clinical outcome

Date:
November 14, 2008
Source:
American Society of Human Genetics
Summary:
Scientists have found that in-common genetic alterations in both cancerous cells and the surrounding normal-looking cells (called tumor microenvironment or stroma) play an important role in predicting and dictating the outcome of three cancer types: breast cancer (BC), prostate cancer (CaP) and head neck squamous cell carcinomas (HNSCC).

A team of researchers led by Charis Eng, M.D., Ph.D., Chair and Director of Cleveland Clinic's Genomic Medicine Institute, has found that in-common genetic alterations in both cancerous cells and the surrounding normal-looking cells (called tumor microenvironment or stroma) play an important role in predicting and dictating the outcome of three cancer types: breast cancer (BC), prostate cancer (CaP) and head neck squamous cell carcinomas (HNSCC).

The findings not only offer important clues into how a cancer and its micro-environment interact, but show that in-common biomarkers may be important for prognosis among several solid tumor types.

Eng's research team hypothesized that frequent genetic alterations are in-common in BC, CaP and HNSCC, but genetic alterations that are associated with clinicopathological features are unique for specific cancer types. The study analyzed tissue samples from 413 patients and evaluated the cancerous (epithelial) and the surrounding stroma.

The researchers found 15-genetic-marker profiles that were in-common for the three cancer types and are likely to simultaneously predict or explain the cancers. Of these genetic-markers, 11 were stromal-specific, two were epithelial-specific, and two were in both compartments (epithelium and stroma). They also found a genetic-marker that was strongly associated with tumor-grade in CaP and BC only, and another one was associated with nodal metastases in BC and HNSCC only, in both compartments.

"Furthering our understanding of how multiple genetic factors interact between cancer cells and its micro-environment, or stroma, will be a valuable tool for clinicians in predicting how a cancer might spread, as well as forecasting patient outcomes," Eng stated. "Importantly, fewer molecular targets for treatment or prevention across several common carcinomas will facilitate more precise and compartment-specific therapeutic options."

Charis Eng, M.D., Ph.D., is the Director and Chair of the Cleveland Clinic Genomic Medicine Institute, and Professor and Vice Chairman of the Department of Genetics at Case Western Reserve University School of Medicine. Dr. Eng currently serves on the ASHG's Board of Directors. She also serves as Chair of the Clinical Science Committee for the Personalized Medicine Coalition (PMC).

This research was presented at the 58th Annual Meeting of The American Society of Human Genetics (ASHG) in Philadelphia, Pennsylvania on November 11-15, 2008.


Story Source:

The above story is based on materials provided by American Society of Human Genetics. Note: Materials may be edited for content and length.


Cite This Page:

American Society of Human Genetics. "Common and cancer type-specific loss-of-heterozygosity in tumor stroma and epithelium of three carcinoma types associated with clinical outcome." ScienceDaily. ScienceDaily, 14 November 2008. <www.sciencedaily.com/releases/2008/11/081114115811.htm>.
American Society of Human Genetics. (2008, November 14). Common and cancer type-specific loss-of-heterozygosity in tumor stroma and epithelium of three carcinoma types associated with clinical outcome. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/11/081114115811.htm
American Society of Human Genetics. "Common and cancer type-specific loss-of-heterozygosity in tumor stroma and epithelium of three carcinoma types associated with clinical outcome." ScienceDaily. www.sciencedaily.com/releases/2008/11/081114115811.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins