Featured Research

from universities, journals, and other organizations

Widely Used Cancer Drug Associated With Significantly Increased Risk Of Blood Clots

Date:
November 22, 2008
Source:
JAMA and Archives Journals
Summary:
The use of the cancer drug bevacizumab is associated with an increased risk of venous thromboembolism (blood clots in the deep veins of the legs or in the lungs), according to a new article.

An analysis of randomized controlled trials indicates that use of the cancer drug bevacizumab is associated with an increased risk of venous thromboembolism (blood clots in the deep veins of the legs or in the lungs), according to a new article in JAMA.

Angiogenesis, a process involving the proliferation of new blood vessels, plays a crucial role in the growth and metastasis of cancer. Bevacizumab, a new, widely-used angiogenesis inhibitor, has shown benefits in the treatment of many types of malignancy including colorectal cancer, non–small cell lung cancer (NSCLC), renal cell cancer and breast cancer. Concerns have arisen regarding the use of bevacizumab and the risk of venous thromboembolism, one of the leading causes of illness and death in patients with cancer.

To determine the risk of venous thromboembolism associated with bevacizumab use, Shobha Rani Nalluri, M.D., of Stony Brook University, Stony Brook, N.Y., and colleagues conducted a meta-analysis of 15 randomized controlled trials (RCTs), which included a total of 7,956 patients with a variety of advanced solid tumors.

The researchers found that among patients receiving bevacizumab, the incidence of all-grade venous thromboembolism was 11.9 percent, and for high-grade venous thromboembolism, it was 6.3 percent. The risk of developing venous thromboembolism was 33 percent greater with bevacizumab than with controls. The risk was significantly increased for both all-grade and high-grade venous thromboembolism. Both high (5 mg/kg per week) and low (2.5 mg/kg per week) doses of bevacizumab were associated with a 31 percent increased risk of venous thromboembolism.

The incidence of all-grade venous thromboembolism with bevacizumab varied among different tumors. The highest incidence was observed among patients with colorectal cancer (19.1 percent); for patients with NSCLC, the incidence was 14.9 percent, while for patients with breast cancer, the incidence of all-grade venous thromboembolism was 7.3 percent. The lowest incidence was seen in patients with renal cancer at 3.0 percent.

"The association of venous thromboembolism with new agents presents a challenge for recognition because many RCTs may not be powered to reveal a significant relationship. Our meta-analysis of 15 RCTs has overcome this limitation of individual trials and demonstrated that bevacizumab may be associated with a significantly increased risk of venous thromboembolism in patients with a variety of metastatic solid tumors. The increased risk is observed not only for all-grade venous thromboembolism, but also for clinically significant high-grade venous thromboembolism. This finding will help physicians and patients to recognize the risk of venous thromboembolism with the administration of bevacizumab," the authors write.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shobha Rani Nalluri, MD; David Chu, MD; Roger Keresztes, MD; Xiaolei Zhu, MD, PhD; Shenhong Wu, MD, PhD. Risk of Venous Thromboembolism With the Angiogenesis Inhibitor Bevacizumab in Cancer Patients. JAMA, 2008;300(19):2277-2285 [link]

Cite This Page:

JAMA and Archives Journals. "Widely Used Cancer Drug Associated With Significantly Increased Risk Of Blood Clots." ScienceDaily. ScienceDaily, 22 November 2008. <www.sciencedaily.com/releases/2008/11/081118161236.htm>.
JAMA and Archives Journals. (2008, November 22). Widely Used Cancer Drug Associated With Significantly Increased Risk Of Blood Clots. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2008/11/081118161236.htm
JAMA and Archives Journals. "Widely Used Cancer Drug Associated With Significantly Increased Risk Of Blood Clots." ScienceDaily. www.sciencedaily.com/releases/2008/11/081118161236.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins