Featured Research

from universities, journals, and other organizations

Reliability Of Cognitive Assessment Tool Varies Widely, Study Suggests

Date:
November 24, 2008
Source:
IOS Press
Summary:
The reliability of the Alzheimer's Disease Assessment Scale -- Cognitive may vary and possess the ability to affect clinical trial outcomes, a new study suggests.

A new suggests the reliability of the Alzheimer's Disease Assessment Scale – Cognitive (ADAS-Cog) may vary and possess the ability to affect clinical trial outcomes.

Moreover, this study further suggests that ADAS-Cog rater training and experience are factors that contribute to variances seen in this assessment tool.

The importance of a reliable diagnosis of the Alzheimer's disease (AD) is critical as new pharmacotherapies are being developed. The ADAS-cog is considered the gold-standard and the most popular cognitive testing instrument used in clinical trials to detect changes in the core symptoms of AD.

This study critically looks at various factors that might influence the way the ADAS-cog is administered and therefore may lead to and yield unintended outcomes. The study found factors such as rater training, rater education, variance in time allotment during testing as well as rater experience and individual judgment may contribute to variance in scoring when using this assessment.

"Clinical trials for the possible treatment of Alzheimer's disease and other dementias are becoming more expansive and being run in many countries. The necessity for the primary outcome instrument to be administered consistently in different countries, cultures and between different clinical trials is critical if we are to determine which treatment works better than others. Any variability in how the instruments are administered can adversely affect the ability to detect positive outcomes," says Donald Connor PhD, PhD, director of neuropsychology at Banner Health's Sun Health Research Institute.

Rater experiences were not the only factors that contributed to variances in ADAS-cog scoring. The study also suggested that test materials changed over time including large ranges in the quality of naming materials, word card decks, instruction manuals and worksheets, all factors that can affect outcomes.

"Even as we try to develop better instruments for the detection of meaningful change we must make sure that our current instruments are utilized as effectively as possible," Dr. Connor says. "As the population continues to age rapidly and new Alzheimer's medications are being developed, it is critical that all who are involved in clinical evaluation and testing does so with precision and consistency."

The study is published in the November issue of the Journal of Alzheimer's Disease (Volume 15:3).


Story Source:

The above story is based on materials provided by IOS Press. Note: Materials may be edited for content and length.


Cite This Page:

IOS Press. "Reliability Of Cognitive Assessment Tool Varies Widely, Study Suggests." ScienceDaily. ScienceDaily, 24 November 2008. <www.sciencedaily.com/releases/2008/11/081124165301.htm>.
IOS Press. (2008, November 24). Reliability Of Cognitive Assessment Tool Varies Widely, Study Suggests. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2008/11/081124165301.htm
IOS Press. "Reliability Of Cognitive Assessment Tool Varies Widely, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/11/081124165301.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins