Featured Research

from universities, journals, and other organizations

Hypersensitivity Reactions To The Quadrivalent HPV Vaccine Are Rare, Study Finds

Date:
December 2, 2008
Source:
BMJ-British Medical Journal
Summary:
Hypersensitivity reactions to the quadrivalent HPV vaccine (4vHPV, Gardasil) are uncommon and most schoolgirls can tolerate subsequent doses, finds the first evaluation of the quadrivalent HPV vaccine.

Hypersensitivity reactions to the quadrivalent HPV vaccine (4vHPV, Gardasil) are uncommon and most schoolgirls can tolerate subsequent doses, finds the first evaluation of the quadrivalent HPV vaccine published on bmj.com.

In Australia, from April 2007, all females aged 12󈞆 years received the 4vHPV vaccine as part of a national secondary school immunisation programme. Some components of the vaccine such as aluminium salts and yeast have previously been associated with hypersensitivity reactions. Reports of some adverse events followed the school vaccination programme.

Dr Sharon Choo and colleagues from Australia describe the results of clinical evaluation, skin tests, and vaccine challenge in 25 schoolgirls with suspected hypersensitivity to 4vHPV after more than 380,000 vaccine doses were administered in schools in Victoria and South Australia.

Thirty five schoolgirls with suspected hypersensitivity reactions including urticaria (hives), generalised rash, angioedema (swelling of subcutaneous tissues) and anaphylaxis were reported to specialised immunisation services and 25 agreed to be referred to paediatric allergy centres for further evaluation.

A detailed account of the reactions was noted including previous doses of the vaccine, time and severity of reaction, and previous clinical history. Skin prick tests of the quadrivalent and bivalent HPV vaccines were carried out, and vaccine challenges were administered intramuscularly. The school-girls were followed-up by telephone one week after the subsequent dose and any adverse events were recorded.

The researchers report that 19 girls had skin testing of the quadrivalent vaccine and all were negative. Seventeen of the 18 girls subsequently challenged with the quadrivalent vaccine tolerated further doses. One reported limited urticaria (hives) four hours after the vaccine was given.

Only three of the 25 evaluated schoolgirls had probable hypersensitivity to the quadrivalent vaccine, and the authors conclude that true hypersensitivity is uncommon. They point out that suspected hypersensitivity reactions such as hives are often "idiosyncratic" and do not increase the risk of adverse reactions in subsequent vaccinations.

The authors recommend that girls with suspected hypersensitivity to the quadrivalent vaccine should be evaluated before receiving more doses, and call for research into the mechanisms of hypersensitivity to the vaccine.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

BMJ-British Medical Journal. "Hypersensitivity Reactions To The Quadrivalent HPV Vaccine Are Rare, Study Finds." ScienceDaily. ScienceDaily, 2 December 2008. <www.sciencedaily.com/releases/2008/12/081202191315.htm>.
BMJ-British Medical Journal. (2008, December 2). Hypersensitivity Reactions To The Quadrivalent HPV Vaccine Are Rare, Study Finds. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2008/12/081202191315.htm
BMJ-British Medical Journal. "Hypersensitivity Reactions To The Quadrivalent HPV Vaccine Are Rare, Study Finds." ScienceDaily. www.sciencedaily.com/releases/2008/12/081202191315.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins