Featured Research

from universities, journals, and other organizations

Smoking Associated With Increased Risk For Colorectal Cancer And Death

Date:
December 18, 2008
Source:
JAMA and Archives Journals
Summary:
An analysis of previous studies indicates that smoking is significantly associated with an increased risk for colorectal cancer and death, according to a new article.

An analysis of previous studies indicates that smoking is significantly associated with an increased risk for colorectal cancer and death, according to a new article.

Although tobacco was responsible for approximately 5.4 million deaths in 2005, there are still an estimated 1.3 billion smokers in the world. While a number of cancers are attributable to smoking, the link between cigarette smoking and colorectal cancer (CRC) has been inconsistent among studies. "Because smoking can potentially be controlled by individual and population-related measures, detecting a link between CRC and smoking could help reduce the burden of the world's third most common tumor, which currently causes more than 500,000 annual deaths worldwide. In the United States alone, an estimate of approximately 50,000 deaths from CRC would have occurred in 2008," the authors write.

Edoardo Botteri, M.Sc., of the European Institute of Oncology, Milan, Italy, and colleagues conducted a meta-analysis to review and summarize published data examining the link between smoking and CRC incidence and death.

The researchers identified 106 observational studies, and the meta-analysis was based on a total of nearly 40,000 new cases of CRC. For the analysis on incidence, smoking was associated with an 18 percent increased risk of CRC. The researchers also found a statistically significant dose-relationship with an increasing number of pack-years (number of packs of cigarettes smoked/day, multiplied by years of consumption) and cigarettes per day. However, the association was statistically significant only after 30 years of smoking.

Seventeen studies were included in the analysis of mortality, which indicated that smokers have a 25 percent increased risk of dying from CRC than people who have never smoked. There also was an increase in risk of CRC death with increasing number of cigarettes per day smoked and for longer duration of smoking. For both incidence and death, the association was stronger for cancer of the rectum than of the colon.

"Smoking has not been considered so far in the stratification of individuals for CRC screening. However, several studies reported that CRC occurs earlier in smokers, particularly in those with heavy tobacco consumption, and our previous and present findings provide strong evidence of the detrimental effect of cigarette smoking on the development of adenomatous [benign tumor] polyps and CRC. We believe that smoking represents an important factor to consider when deciding on the age at which CRC screening should begin, either by lowering the age in smokers or increasing the age in non-smokers," the authors write.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Edoardo Botteri; Simona Iodice; Vincenzo Bagnardi; Sara Raimondi; Albert B. Lowenfels; Patrick Maisonneuve. Smoking and Colorectal Cancer: A Meta-analysis. JAMA, 2008;300(23):2765-2778 [link]

Cite This Page:

JAMA and Archives Journals. "Smoking Associated With Increased Risk For Colorectal Cancer And Death." ScienceDaily. ScienceDaily, 18 December 2008. <www.sciencedaily.com/releases/2008/12/081216161050.htm>.
JAMA and Archives Journals. (2008, December 18). Smoking Associated With Increased Risk For Colorectal Cancer And Death. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2008/12/081216161050.htm
JAMA and Archives Journals. "Smoking Associated With Increased Risk For Colorectal Cancer And Death." ScienceDaily. www.sciencedaily.com/releases/2008/12/081216161050.htm (accessed September 30, 2014).

Share This



More Mind & Brain News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Do Video Games Trump Brain Training For Cognitive Boosts?

Do Video Games Trump Brain Training For Cognitive Boosts?

Newsy (Sep. 29, 2014) More and more studies are showing positive benefits to playing video games, but the jury is still out on brain training programs. Video provided by Newsy
Powered by NewsLook.com
Your Spouse's Personality May Influence Your Earnings

Your Spouse's Personality May Influence Your Earnings

Newsy (Sep. 26, 2014) Research from Washington University suggest people with conscientious spouses have greater career success. Video provided by Newsy
Powered by NewsLook.com
Can A Blood Test Predict Psychosis Risk?

Can A Blood Test Predict Psychosis Risk?

Newsy (Sep. 26, 2014) Researchers say certain markers in the blood can predict risk of psychosis later in the life. The test can aid in early treatment for the condition. Video provided by Newsy
Powered by NewsLook.com
Harpist Soothes Gorillas, Orangutans With Music

Harpist Soothes Gorillas, Orangutans With Music

AP (Sep. 25, 2014) Teri Tacheny, a harpist, has a loyal following of fans who appreciate her soothing music. Every month, gorillas, orangutans and monkeys amble down to hear her play at the Como Park Zoo in Minnesota. (Sept. 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins