Featured Research

from universities, journals, and other organizations

Nerve cell defect contributes to multiple sclerosis

Date:
December 22, 2008
Source:
Journal of Clinical Investigation
Summary:
Multiple sclerosis (MS) is an inflammatory disease of the brain and spinal cord that progresses overtime, with increasing disability. It occurs when the immune system inappropriately attacks both the sheath that insulates and protects the nerve cells and the cells that make this sheath, oligodendrocytes.

Multiple sclerosis (MS) is an inflammatory disease of the brain and spinal cord that progresses overtime, with increasing disability. It occurs when the immune system inappropriately attacks both the sheath that insulates and protects the nerve cells and the cells that make this sheath, oligodendrocytes.

Related Articles


One question regarding the disease is why precursors of oligodendrocytes are still present in diseased areas of the brain of individuals with MS but do not develop into oligodendrocytes and produce the nerve cell sheath. However, Jin Nakahara and colleagues, at Keio University School of Medicine, Japan, have now provided insight into this issue through analysis of brain tissue from MS patients and rodent cell lines in vitro.

In the study, damaged nerve cells in diseased areas of the brain of individuals with MS were found to express high levels of the protein Contactin, which interacted with the protein Notch1 on precursors of oligodendrocytes. In normal tissues, this triggers a signaling pathway that induces the precursors to develop into oligodendrocytes. However, in the diseased areas of the brain of individuals with MS these signaling events did not occur normally. Specifically, a protein known as TIP30 was abnormally overexpressed, preventing a key signaling component (the Notch1 intracellular domain) from performing its function. The authors therefore conclude that this signaling defect contributes to the development of MS.

In an accompanying commentary, Celia Brosnan and Gareth R. John highlight the key aspects of the study and discuss the implications for our understanding of MS.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nakahara et al. Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis. Journal of Clinical Investigation, Dec 22, 2008; DOI: 10.1172/JCI35440

Cite This Page:

Journal of Clinical Investigation. "Nerve cell defect contributes to multiple sclerosis." ScienceDaily. ScienceDaily, 22 December 2008. <www.sciencedaily.com/releases/2008/12/081222221453.htm>.
Journal of Clinical Investigation. (2008, December 22). Nerve cell defect contributes to multiple sclerosis. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2008/12/081222221453.htm
Journal of Clinical Investigation. "Nerve cell defect contributes to multiple sclerosis." ScienceDaily. www.sciencedaily.com/releases/2008/12/081222221453.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins