Featured Research

from universities, journals, and other organizations

Bone Marrow Cells Help Repair Damaged Lung

Date:
January 27, 2009
Source:
Journal of Clinical Investigation
Summary:
Scientists have identified a population of mouse bone marrow cells that can contribute to repair of the injured lung. As cells expressing similar markers were identified in human bone marrow, the authors suggest that this cell population might be used therapeutically to treat individuals with diseases characterized by damage to the lining of the lungs.

Thomas Waddell and colleagues, at Toronto General Research Institute, Toronto, have identified a population of mouse bone marrow cells that can contribute to repair of the injured lung. As cells expressing similar markers were identified in human bone marrow, the authors suggest that this cell population might be used therapeutically to treat individuals with diseases characterized by damage to the lining of the lungs.

Related Articles


In the study, a population of cells expressing the protein CCSP was identified in the bone marrow of both humans and mice. When cultured ex vivo these cells expressed markers of lung epithelial cells, the cells that line the lungs, and when the mouse cells were injected into mice they migrated to damaged lung tissue.

Further analysis showed that if mice lacking CCSP were transplanted with CCSP-sufficient bone marrow, cells derived from the CCSP-expressing bone marrow could be found in the lining of the lungs after they had been damaged.

The authors therefore suggest that by determining that CSSP-expressing bone marrow cells can contribute to reconstitution of the lining of the lung after damage, they have reconciled previous controversies regarding the ability of bone marrow cells to be a factor in lung regeneration.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wong et al. Identification of a bone marrow–derived epithelial-like population capable of repopulating injured mouse airway epithelium. Journal of Clinical Investigation, jan 29, 2009; DOI: 10.1172/JCI36882

Cite This Page:

Journal of Clinical Investigation. "Bone Marrow Cells Help Repair Damaged Lung." ScienceDaily. ScienceDaily, 27 January 2009. <www.sciencedaily.com/releases/2009/01/090126173614.htm>.
Journal of Clinical Investigation. (2009, January 27). Bone Marrow Cells Help Repair Damaged Lung. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2009/01/090126173614.htm
Journal of Clinical Investigation. "Bone Marrow Cells Help Repair Damaged Lung." ScienceDaily. www.sciencedaily.com/releases/2009/01/090126173614.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins