Featured Research

from universities, journals, and other organizations

Loop Diuretics And Fractures In Postmenopausal Women Studied

Date:
January 29, 2009
Source:
JAMA and Archives Journals
Summary:
Short-term use of loop diuretics does not appear to be associated with changes in bone mineral density, falls or fractures in postmenopausal women, according to a new report. However, prolonged use of loop diuretics may increase fracture risk in this group.

The use of loop diuretics does not appear to be associated with changes in bone mineral density, falls or fractures in postmenopausal women, according to a new report. However, prolonged use of loop diuretics may increase fracture risk in this group.

Related Articles


Developing osteoporosis and heart failure are of particular concern for many postmenopausal women; half of them experience osteoporosis-related fractures in their lifetime and at age 40 their lifetime risk for developing heart failure is one in five, according to background information in the article. Loop diuretics are commonly prescribed for the treatment of congestive heart failure. These agents "increase calcium excretion and, in some studies, hypercalciuria is associated with low bone mineral density, a risk factor for fractures," the authors note.

Laura D. Carbone, M.D., M.S., of the University of Tennessee Health Science Center, Memphis, and colleagues examined the use of loop diuretics and changes in bone mineral density, falls and fractures in 133,855 women enrolled in the Women's Health Initiative (WHI) from October 1993 to December 1998. Bone mineral density was measured for 300 diuretic users and 9,124 non-users at baseline and at year three of the study. Falls and fractures were recorded for an average of 7.7 years.

Of the participants, 3,411 used loop diuretics and 130,444 did not. The association between loop diuretic use and total fractures, hip fractures, clinical vertebral fractures and falls was not significant. However, women who had used loop diuretics for more than three years had modest increased risks for other clinical fractures and total fractures.

"No significant differences were found between loop diuretic users and nonusers in baseline bone mineral density of the total hip, lumbar spine, total body, year three bone mineral density of the total hip, lumbar spine, total body or change in bone mineral density measurements from baseline to year three," the authors write.

"In conclusion, no significant association was found between ever use of loop diuretics and changes in bone mineral density, falls or fractures in postmenopausal women in the WHI. However, prolonged use of loop diuretics was associated with higher fracture risk in postmenopausal women," the authors write. "Therefore, it may be important to consider fracture prevention measures in women who receive loop diuretic therapy."

Editor's Note: The WHI Program is funded by the National Heart, Lung, and Blood Institute of Health, U.S. Public Health Service contract.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Carbone et al. Loop Diuretic Use and Fracture in Postmenopausal Women: Findings From the Women's Health Initiative. Archives of Internal Medicine, 2009; 169 (2): 132 DOI: 10.1001/archinternmed.2008.526

Cite This Page:

JAMA and Archives Journals. "Loop Diuretics And Fractures In Postmenopausal Women Studied." ScienceDaily. ScienceDaily, 29 January 2009. <www.sciencedaily.com/releases/2009/01/090126173715.htm>.
JAMA and Archives Journals. (2009, January 29). Loop Diuretics And Fractures In Postmenopausal Women Studied. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2009/01/090126173715.htm
JAMA and Archives Journals. "Loop Diuretics And Fractures In Postmenopausal Women Studied." ScienceDaily. www.sciencedaily.com/releases/2009/01/090126173715.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins