Featured Research

from universities, journals, and other organizations

Teen Smoking Could Lead To Adult Depression, Study Says

Date:
February 6, 2009
Source:
Florida State University
Summary:
Teenagers who smoke could be setting themselves up for depression later in life, according to a new study.

Carlos A. Bolaños.
Credit: Image courtesy of Florida State University

 Teenagers who smoke could be setting themselves up for depression later in life, according to a groundbreaking new Florida State University study.

Related Articles


Psychology Professor Carlos Bolanos and a team of researchers found that nicotine given to adolescent rats induced a depression-like state characterized by a lack of pleasure and heightened sensitivity to stress in their adult lives. The findings suggest that the same may be true for humans.

"This study is unique because it is the first one to show that nicotine exposure early in life can have long-term neurobiological consequences evidenced in mood disorders," Bolanos said. "In addition, the study indicates that even brief exposure to nicotine increases risk for mood disorders later in life."

The Florida State researchers injected adolescent rats twice daily with either nicotine or saline for 15 days. After the treatment period ended, they subjected the rats to several experiments designed to find out how they would react to stressful situations as well as how they would respond to the offering of rewards.

They found that behavioral changes symptomatic of depression can emerge after one week of nicotine cessation and -- most surprising -- that even a single day of nicotine exposure during adolescence can have long-lasting effects.

"Some of the animals in our study were exposed to nicotine once and never saw the drug again," Bolanos said. "It was surprising to us to discover that a single day of nicotine exposure could potentially have such long-term negative consequences."

The rats that were exposed to nicotine engaged in behaviors symptomatic of depression and anxiety, including repetitive grooming, decreased consumption of rewards offered in the form of sugary drinks and becoming immobile in stressful situations instead of engaging in typical escape-like behaviors. The researchers were able to alleviate the rats' symptoms with antidepressant drugs or, ironically, more nicotine.

Interestingly, adult rodents that were exposed to the same nicotine regimen as the adolescents did not display depression-like traits. It is not known exactly how nicotine works on the brain and nervous system to induce these effects, but exposure has toxic effects in several brain regions and neurotransmitter systems at distinct periods of development, Bolanos said.

Because various neurotransmitter systems in the brain continue to develop throughout adolescence, the researchers theorize that nicotine may negatively influence these systems resulting in altered functionality later in life. The study's findings underscore the need for further research into how this process occurs.

Scientists have long known there is a connection between smoking and mood disorders, but they have not been able to say for sure that one causes the other because there are so many factors influencing human behavior. This study provides support for the idea that smoking can induce symptoms of depression, and paradoxically, can also be a way of managing those same symptoms and enhancing the risk for addiction.

"The message to young people of course is don't smoke and don't even try it," Bolanos said. "If they do smoke, they need to be aware of the potentially long-term effects that recreational or even occasional cigarette smoking can have on their systems."

The work was supported by grants from the state of Florida's James and Esther King Biomedical Research Program and the National Institute on Drug Abuse. In addition, Iniguez has a McKnight Fellowship from the Florida Education Fund and a Neuroscience Fellowship from Florida State University. Warren also is supported by a Neuroscience Fellowship.


Story Source:

The above story is based on materials provided by Florida State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Iñiguez et al. Nicotine Exposure During Adolescence Induces a Depression-Like State in Adulthood. Neuropsychopharmacology, 2008; DOI: 10.1038/npp.2008.220

Cite This Page:

Florida State University. "Teen Smoking Could Lead To Adult Depression, Study Says." ScienceDaily. ScienceDaily, 6 February 2009. <www.sciencedaily.com/releases/2009/01/090129113323.htm>.
Florida State University. (2009, February 6). Teen Smoking Could Lead To Adult Depression, Study Says. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2009/01/090129113323.htm
Florida State University. "Teen Smoking Could Lead To Adult Depression, Study Says." ScienceDaily. www.sciencedaily.com/releases/2009/01/090129113323.htm (accessed February 28, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, February 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) — If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com
Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) — People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) — Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Marijuana Nowhere Near As Deadly As Alcohol: Study

Marijuana Nowhere Near As Deadly As Alcohol: Study

Newsy (Feb. 25, 2015) — A new study says marijuana is about 114 times less deadly than alcohol. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins