Featured Research

from universities, journals, and other organizations

SSRIs May Reduce Suicide In Adults

Date:
February 10, 2009
Source:
Canadian Medical Association Journal
Summary:
Selective serotonin reuptake inhibitors (SSRIs) may reduce the risk of suicide in depressed adults, according to a new study.

Selective serotonin reuptake inhibitors (SSRIs) may reduce the risk of suicide in depressed adults, according to a study by researchers from the World Health Organization and the University of Verona, Italy published in CMAJ.

The study, a meta-analysis of 8 large-scale observational studies, was undertaken to explore whether SSRIs reduce or increase the risk of suicide in depressed people.

Previous studies, including a 2007 study by the U.S. Food and Drug Administration (FDA), found the risk of suicide in adults was neutral, elevated in those under 25 and reduced in people older than 65. A subsequent black box warning was added to all antidepressants regarding increased risk of suicidal symptoms in people under 25 years of age.

"While the FDA analysis found a neutral effect of SSRIs (or a promoting effect in adults aged 18-25), we found a strong protective effect associated with SSRI treatment in adults," Dr. Corrado Barbui and colleagues. SSRIs in adults significantly reduced the risk of completed or attempted suicide.

They conclude "data from observational studies should reassure doctors that prescribing serotonin reuptake inhibitors in patients with major depression is safe," although children and adolescents should be closely monitored due to the possibility of suicidal thoughts and suicide.

In a related commentary, Dr. John Mann of Columbia University and Dr. Robert Gibbons of the University of Illinois write "alarmingly, concerns about the risk of suicide in youth have led not only to fewer SSRI prescriptions without substitution of alternative medications or psychotherapies, but also to a decrease in predicted rates of diagnosis of mood disorders." They suggest doctors may be avoiding making diagnoses and call for randomized controlled trials to determine safety and efficacy of treatments for young adults


Story Source:

The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Barbui et al. Selective serotonin reuptake inhibitors and risk of suicide: a systematic review of observational studies. CMAJ, 2009; 180: 291-297 [link]

Cite This Page:

Canadian Medical Association Journal. "SSRIs May Reduce Suicide In Adults." ScienceDaily. ScienceDaily, 10 February 2009. <www.sciencedaily.com/releases/2009/02/090202174504.htm>.
Canadian Medical Association Journal. (2009, February 10). SSRIs May Reduce Suicide In Adults. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2009/02/090202174504.htm
Canadian Medical Association Journal. "SSRIs May Reduce Suicide In Adults." ScienceDaily. www.sciencedaily.com/releases/2009/02/090202174504.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins