Feb. 2, 2009 Immune cells that secrete the soluble molecule IL-17 (so called Th17 cells) have been implicated as central to several autoimmune diseases.
However, whether they contribute to the autoimmune disease type 1 diabetes, which is commonly linked to immune cells that secrete the soluble molecule IFN-gamma (so called Th1 cells), has not been clearly determined.
While investigating this in a mouse model of type 1 diabetes, Anne Cooke and colleagues, at the University of Cambridge, United Kingdom, found that highly purified Th17 cells could cause diabetes in NOD/SCID mice, but that they converted to IFN-gamma secreting cells to do this, indicating that Th17 cells show substantial plasticity.
The research appears online, Feb. 2nd, 2009, in the Journal of Clinical Investigation.
Other social bookmarking and sharing tools:
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
- David Bending, Hugo De La Peña, Marc Veldhoen, Jenny M. Phillips, Catherine Uyttenhove, Brigitta Stockinger, Anne Cooke. Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J. Clin. Invest., 2009; DOI: 10.1172/JCI37865
Note: If no author is given, the source is cited instead.