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Th17 Cells Convert To IFN-gamma Secretion To Cause Diabetes

Date:
February 2, 2009
Source:
Journal of Clinical Investigation
Summary:
Immune cells that secrete the soluble molecule IL-17 (so called Th17 cells) have been implicated as central to several autoimmune diseases. However, whether they contribute to the autoimmune disease type 1 diabetes, which is commonly linked to immune cells that secrete the soluble molecule IFN-gamma (so called Th1 cells), has not been clearly determined.

Immune cells that secrete the soluble molecule IL-17 (so called Th17 cells) have been implicated as central to several autoimmune diseases.

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However, whether they contribute to the autoimmune disease type 1 diabetes, which is commonly linked to immune cells that secrete the soluble molecule IFN-gamma (so called Th1 cells), has not been clearly determined.

While investigating this in a mouse model of type 1 diabetes, Anne Cooke and colleagues, at the University of Cambridge, United Kingdom, found that highly purified Th17 cells could cause diabetes in NOD/SCID mice, but that they converted to IFN-gamma secreting cells to do this, indicating that Th17 cells show substantial plasticity.

The research appears online, Feb. 2nd, 2009, in the Journal of Clinical Investigation.


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The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. David Bending, Hugo De La Peña, Marc Veldhoen, Jenny M. Phillips, Catherine Uyttenhove, Brigitta Stockinger, Anne Cooke. Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J. Clin. Invest., 2009; DOI: 10.1172/JCI37865

Cite This Page:

Journal of Clinical Investigation. "Th17 Cells Convert To IFN-gamma Secretion To Cause Diabetes." ScienceDaily. ScienceDaily, 2 February 2009. <www.sciencedaily.com/releases/2009/02/090202215010.htm>.
Journal of Clinical Investigation. (2009, February 2). Th17 Cells Convert To IFN-gamma Secretion To Cause Diabetes. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2009/02/090202215010.htm
Journal of Clinical Investigation. "Th17 Cells Convert To IFN-gamma Secretion To Cause Diabetes." ScienceDaily. www.sciencedaily.com/releases/2009/02/090202215010.htm (accessed November 1, 2014).

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