Featured Research

from universities, journals, and other organizations

Rituximab Maintenance Therapy Improves Survival In Patients With Relapsed Follicular Lymphoma

Date:
February 10, 2009
Source:
Journal of the National Cancer Institute
Summary:
Patients with relapsed or refractory follicular lymphoma who continue on maintenance rituximab therapy after chemotherapy have better overall survival than patients who do not receive this treatment, according to a meta-analysis of randomized trials in the Journal of the National Cancer Institute.

Patients with relapsed or refractory follicular lymphoma who continue on maintenance rituximab therapy after chemotherapy have better overall survival than patients who do not receive this treatment, according to a meta-analysis of randomized trials.

Most patients with follicular lymphoma respond to initial therapy but many experience disease relapse. Previous trials have showed that rituximab plus chemotherapy improves overall survival in these patients compared with chemotherapy alone. However, it has not been clear if continuing rituximab treatment beyond the completion of chemotherapy further prolongs overall survival.

To determine the impact of maintenance rituximab on overall survival, Liat Vidal, M.D., of the Rabin Medical Center in Petah-Tikva, Israel, and colleagues pooled data from five randomized trials that compared maintenance therapy with no maintenance therapy. Overall survival data were available for 985 patients.

Rituximab maintenance therapy was associated with a 40% improvement in overall survival relative to observation or retreatment with rituximab at relapse. The improvement in overall survival was statistically significant for patients with relapsed or refractory lymphoma, but not for previously untreated patients. Patients treated with rituximab maintenance therapy, however, had nearly twice the rate of infection-related adverse events as patients who did not have prolonged rituximab therapy.

"Our results suggest that rituximab maintenance therapy for up to 2 years, either as four weekly infusions every 6 months or as a single infusion every 2 – 3 months, should be added to standard therapy of patients with relapsed or refractory follicular lymphoma after successful induction treatment," the authors write. "The higher rate of infections with rituximab therapy should be taken into consideration when making treatment decisions."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Vidal et al. Rituximab Maintenance for the Treatment of Patients With Follicular Lymphoma: Systematic Review and Meta-analysis of Randomized Trials. JNCI Journal of the National Cancer Institute, 2009; DOI: 10.1093/jnci/djn478

Cite This Page:

Journal of the National Cancer Institute. "Rituximab Maintenance Therapy Improves Survival In Patients With Relapsed Follicular Lymphoma." ScienceDaily. ScienceDaily, 10 February 2009. <www.sciencedaily.com/releases/2009/02/090210161854.htm>.
Journal of the National Cancer Institute. (2009, February 10). Rituximab Maintenance Therapy Improves Survival In Patients With Relapsed Follicular Lymphoma. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2009/02/090210161854.htm
Journal of the National Cancer Institute. "Rituximab Maintenance Therapy Improves Survival In Patients With Relapsed Follicular Lymphoma." ScienceDaily. www.sciencedaily.com/releases/2009/02/090210161854.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins