Featured Research

from universities, journals, and other organizations

Molecular Motors In Cells Work Together, Study Shows

Date:
February 25, 2009
Source:
University of Virginia
Summary:
Molecular motors, the little engines that power cell mobility and the ability of cells to transport internal cargo, work together and in close coordination, according to a new findings. The work could have implications for the treatment of neurodegenerative disorders.

Jeneva Laib, Robert Bloodgood and William Guilford.
Credit: Photo by Dan Addison

Even within cells, the left hand knows what the right hand is doing.

Molecular motors, the little engines that power cell mobility and the ability of cells to transport internal cargo, work together and in close coordination, according to a new finding by researchers at the University of Virginia. The work could have implications for the treatment of neurodegenerative disorders.

"We found that molecular motors operate in an amazingly coordinated manner when moving an algal cell one way or the other," said Jeneva Laib, the lead author and an undergraduate biomedical engineering student at the University of Virginia. "This provides a new understanding of the ways cells move."

The finding appears online in the current issue of The Proceedings of the National Academy of Sciences.

Laib, a second-year student from Lorton, Va., and her collaborators, U.Va. professors Robert Bloodgood and William Guilford, used the alga Chlamydomonas as a model to study how molecular motors in most types of cells work to move internal cargo, such as organelles associated with energy production and nutrient transport, or even the entire cell.

These motions are caused by a line of motors that pull the cell along, like the locomotive on a train. Previous studies had suggested that these motors pulled in opposite directions, like a game of tug of war. More recent studies indicated that the motors were working together rather than independently.

The new U.Va. study provides strong evidence that the motors are indeed working in coordination, all pulling in one direction, as if under command, or in the opposite direction — again, as if under strict instruction.

"We've found that large numbers of these molecular motors are turning on at the same time to generate large amounts of force, and then turning off at the same time to allow transport in the particular direction," said Guilford, Laib's adviser and lab director. "This insight opens up the possibility for us to begin to understand the mechanism that instructs the motors to pull one way or the other."

A greater understanding of cell motility and the ways in which cells move cargo within cells could eventually lead to therapies for neurodegenerative disorders such as amyotrophic lateral sclerosis (Lou Gehrig's Disease), diabetic neuropathy, and Usher syndrome, a progressive loss of hearing and vision. Neurodegenerative diseases can be caused by defects in the transport processes within neural cells.

"You basically get a logjam within the cell that prevents forward progress of these motors and their cargo," Guilford said. "So if we could understand how the motors are normally coordinated inside cells, we might be able to eventually realize therapeutic approaches to restoring transport for cell revival."

"There is some amazing cooperation going on among these motors," noted Bloodgood, a specialist in cell locomotion research. "When one set of as many as 10 motors turn on, another set turns off in unison. Understanding this process could help us to restore this locomotion when defects occur."


Story Source:

The above story is based on materials provided by University of Virginia. Note: Materials may be edited for content and length.


Cite This Page:

University of Virginia. "Molecular Motors In Cells Work Together, Study Shows." ScienceDaily. ScienceDaily, 25 February 2009. <www.sciencedaily.com/releases/2009/02/090213161043.htm>.
University of Virginia. (2009, February 25). Molecular Motors In Cells Work Together, Study Shows. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2009/02/090213161043.htm
University of Virginia. "Molecular Motors In Cells Work Together, Study Shows." ScienceDaily. www.sciencedaily.com/releases/2009/02/090213161043.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins