Featured Research

from universities, journals, and other organizations

Male Infertility Associated With Testicular Cancer

Date:
February 24, 2009
Source:
JAMA and Archives Journals
Summary:
Men who are infertile appear to have an increased risk of developing testicular cancer, according to a new report.

Men who are infertile appear to have an increased risk of developing testicular cancer, according to a report in the February 23 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Testicular germ cell cancer, the most common cancer among young men in industrialized countries, has become even more prevalent during the last 30 to 50 years, according to background information in the article. There is evidence that semen quality and male fertility have also declined during this time in industrialized nations; however, it is unclear whether these two trends are related.

Thomas J. Walsh, M.D., M.S., then of the University of California, San Francisco, and now of the University of Washington School of Medicine, Seattle, and colleagues analyzed data from 22,562 male partners of couples seeking fertility treatment between 1967 and 1998 (4,549 of whom had male factor infertility, based on a clinical presentation with abnormal semen analysis criteria). Their records were linked to the state cancer registry, which includes information about cancer cases confirmed between 1988 and 2004.

A total of 34 of the 22,562 men were diagnosed with testicular cancer at least one year after seeking treatment for infertility. Compared with men of the same age in the general population—whose records were identified using the National Cancer Institute's Surveillance Epidemiology and End Results program—men in couples seeking treatment for infertility were 1.3 times more likely to develop testicular cancer. Men with male factor infertility were 2.8 more likely to develop testicular cancer than those without this condition.

"In interpreting these data, we considered the postulate that male factor infertility or its treatment could cause testicular cancer," the authors write. "However, this theory is highly improbable given that in many cases infertility treatment involves the use of assisted reproductive technologies rather than specific medical or surgical treatment of the male partner." It is also unlikely that the results representing a screening phenomenon, in which men who seek treatment for infertility are diagnosed with a previously unrecognized cancer because of diagnostic testing. Most cases of testicular cancer in adults are diagnosed rapidly when a physical exam reveals a nodule or swelling in the scrotum.

"A more plausible explanation is that a common exposure underlies infertility and testicular cancer," the authors conclude. Faulty DNA repair, or errors in the way the body responds to small areas of damage in its genetic material, may contribute to both conditions, as may environmental factors.

This study was funded by grants from the National Institute of Child Health and Human Development and the California Urology Foundation.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Thomas J. Walsh; Mary S. Croughan; Michael Schembri; June M. Chan; Paul J. Turek. Increased Risk of Testicular Germ Cell Cancer Among Infertile Men. Archives of Internal Medicine, 2009; 169 (4): 351 DOI: 10.1001/archinternmed.2008.562

Cite This Page:

JAMA and Archives Journals. "Male Infertility Associated With Testicular Cancer." ScienceDaily. ScienceDaily, 24 February 2009. <www.sciencedaily.com/releases/2009/02/090223221338.htm>.
JAMA and Archives Journals. (2009, February 24). Male Infertility Associated With Testicular Cancer. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2009/02/090223221338.htm
JAMA and Archives Journals. "Male Infertility Associated With Testicular Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/02/090223221338.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins