Featured Research

from universities, journals, and other organizations

Type 1 Diabetes: Compounds That Trigger Beta Cell Replication Identified

Date:
February 27, 2009
Source:
Juvenile Diabetes Research Foundation International
Summary:
Researchers have identified a set of compounds that can trigger the proliferation of insulin-producing cells in the pancreas, using sophisticated high-throughput screening techniques. This is an initial step in the possible discovery of regenerative medicines for type 1 diabetes.

Researchers at the Genomics Institute of the Novartis Research Foundation (GNF) have identified a set of compounds that can trigger the proliferation of insulin-producing cells in the pancreas, using sophisticated high-throughput screening techniques.

The study, based on screening large numbers of chemical compounds to see if they had any effects on the growth of insulin-producing beta cells, is the first study of its kind, and represents an important initial step in the possible discovery of regenerative medicines for type 1 diabetes.

Type 1 diabetes is an autoimmune disease that affects children, adolescents, and adults, in which the immune system attacks cells in the pancreas that produce insulin, a hormone that enables people to convert food into energy. People with type 1 diabetes are dependent on insulin for the rest of their life. But insulin is not a cure, and people with diabetes are at significant risk for a wide range of serious complications, including heart disease, blindness and kidney disease. As many as 3 million people in the U.S. have type 1 diabetes.

The research team, led by Dr. Peter Schultz, Institute Director at GNF , screened a large chemical "library" or collection of over 850,000 compounds for their effect on a mouse beta cell line. Out of this large collection, approximately 80 compounds showed promise for further investigation, and two, in particular, were studied in greater detail. According to the researchers, one of the two appears to promote beta cell replication via a biological pathway known to be critical for beta cell development in the embryo. A second appears to induce beta cell proliferation via an ion channel, which regulate the flow of ions across cell membranes.

"A number of exciting approaches are being pursued toward the regeneration of beta cell mass for the treatment on type 1 diabetes," said Dr. Peter Schultz. "Our findings show that it is feasible to identify drug-like molecules that induce functional beta cell replication using high throughput screening approaches. We are extending these screens to look for proteins that also might stimulate beta cell replication. The challenge now is to demonstrate the functional efficacy of these compounds in animal models of type 1 diabetes, as well as to show effects on human beta cell replication and function."

JDRF's Regeneration research focuses on triggering the body to regrow the insulin-producing beta cells that have been killed off by type 1 diabetes. This is one of the newest and fastest-growing areas of research JDRF funds. Two lines of approach being considered to regenerate beta cells are spurring the body to copy existing functioning beta cells and coaxing the pancreas to create new ones.

"Targeting beta cell regeneration is still a relatively new approach for the treatment of type 1 diabetes. This study is important in two ways: it is a step toward identifying small molecules that may induce the expansion of beta cells, and it may help reveal the biological mechanisms regulating beta cell expansion," said Patricia Kilian, Director of Regeneration Research at JDRF. "The team at the Genomics Institute of the Novartis Research Foundation is providing new information and insight to help us discover novel therapeutic strategies and approaches to promote beta cell regeneration for type 1 diabetes."

The study, funded by the Juvenile Diabetes Research Foundation, was published in the

Proceedings of the National Academy of Sciences

.


Story Source:

The above story is based on materials provided by Juvenile Diabetes Research Foundation International. Note: Materials may be edited for content and length.


Cite This Page:

Juvenile Diabetes Research Foundation International. "Type 1 Diabetes: Compounds That Trigger Beta Cell Replication Identified." ScienceDaily. ScienceDaily, 27 February 2009. <www.sciencedaily.com/releases/2009/02/090225132536.htm>.
Juvenile Diabetes Research Foundation International. (2009, February 27). Type 1 Diabetes: Compounds That Trigger Beta Cell Replication Identified. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2009/02/090225132536.htm
Juvenile Diabetes Research Foundation International. "Type 1 Diabetes: Compounds That Trigger Beta Cell Replication Identified." ScienceDaily. www.sciencedaily.com/releases/2009/02/090225132536.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins